Disseminated cryptococcosis in an immunocompetent patient

Publication date: Available online 3 March 2020Source: Respiratory Medicine Case ReportsAuthor(s): Rahul Bollam, Mohamed Yassin, Tung Phan
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research

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Cryptococcus neoformans is an opportunistic yeast that is present worldwide and interacts with various organisms. In humans, it is responsible for cryptococcosis, a deadly invasive fungal infection that represents around 220,000 cases per year worldwide. Starting from the natural history of the disease in humans, there is accumulating evidence on the capacity of this organism to enter dormancy. In response to the harsh host environment, the yeast is able to adapt dramatically and escape the vigilance of the host’s immune cells to survive. Indeed, the yeast exposed to the host takes on pleiotropic phenotypes, enabling...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
PMID: 32459503 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Cryptococcosis is a disease of wide geographic distribution. It is most critical when it affects immunocompromised patients, with AIDS, tuberculosis or other diseases that require prolonged hospitalization.
Source: Annals of Clinical Microbiology and Antimicrobials - Category: Microbiology Authors: Tags: Case report Source Type: research
Publication date: Available online 19 May 2020Source: Medical Mycology Case ReportsAuthor(s): Angel Almendros, Daniela H. Muguiro, Fraser I. Hill, Vanessa R. Barrs
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
ABSTRACT Cryptococcosis is caused by yeasts of the Cryptococcus neoformans/C. gattii complex, presenting cutaneous, respiratory and disseminated forms. A 44-year-old immunocompetent male with facial lesion and latent pneumonia was hospitalized and misdiagnosed with paracoccidioidomycosis. Computerized tomography scans showed pulmonary and neurological involvement, and cultures/China ink, cryptococcal antigen test and restriction fragment length polymorphism of urease gene (URA5-RFLP) confirmed C. neoformans genotype VNI. Hemoculture indicated ampicillin-resistant Klebsiella pneumoniae (healthcare-associated infection). Flu...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research
This study aimed to investigate the interaction of MINO and FLU against FLU-resistant C. neoformans both in vitro and in vivo. We found that the combination of MINO and FLU had a synergistic effect on FLU-resistant C. neoformans in vitro. For all FLU-resistant strains, the minimum inhibitory concentration (MIC) of FLU decreased significantly when used in combination with MINO, dropping from>128 μg/ml down to 4–8 μg/ml. Additionally, MINO and FLU had a synergistic effect on both susceptible and resistant C. neoformans biofilms, in which the MIC of FLU decreased from>256 μg/ml down to 4–16 μg/ml...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Pulmonary cryptococcosis is an uncommon infectious disease that can develop in both immunocompromised and immunocompetent patients. The severity of chronic kidney disease (CKD) was reported to be one of the ri...
Source: BMC Pulmonary Medicine - Category: Respiratory Medicine Authors: Tags: Research article Source Type: research
We report a case of systemic cryptococcal infection in an immunosenescent, HIV-negative patient. PMID: 32334491 [PubMed - as supplied by publisher]
Source: New Microbiologica - Category: Microbiology Tags: New Microbiol Source Type: research
Abstract Clinical worsening or new manifestation of cryptococcal disease following initiation of anti-retroviral therapy (ART) in an HIV patient is a hallmark of cryptococcal immune reconstitution inflammatory syndrome (C-IRIS). However, it can be difficult to distinguish IRIS from worsening or new infection. Here, we present a case of severe C-IRIS involving multiple cerebellar, spinal, and intradural abscesses and spinal arachnoiditis 7 months after ART initiation in an AIDS patient with uncertain prior ART compliance. He had multiple prior episodes of cryptococcal meningitis with complications necessitating ven...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
Background: The prevalence of different underlying cryptococcal diseases in human immunodeficiency virus (HIV)-infected patients screened positive for cryptococcal antigenemia and the association between cryptococcal diseases and serum cryptococcal antigen (CrAg) titers were understudied.Methods: HIV-infected patients with CD4
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
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