Elevated Th17 Cell Frequencies and Th17/Treg Ratio Are Associated with Airway Hyperresponsiveness in Asthmatic Children.

Conclusion: Th17 cell, IL-17A and Th17/Treg ratio were positively correlated with AHR in asthmatic children. It may be helpful to monitor Th17 cells and the Th17/Treg ratio as indicators of AHR in clinical practice. PMID: 32114839 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research

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Publication date: Available online 9 July 2020Source: Clinical Epidemiology and Global HealthAuthor(s): Gyan Chandra Kashyap, Santosh Kumar Sharma, Shri Kant Singh
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
Publication date: Available online 9 July 2020Source: Respiratory Physiology &NeurobiologyAuthor(s): Jingxia Chang, Jianan Gao, Lili Lou, Heying Chu, Ping Li, Tengfei Chen, Feng Gao
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research
Conditions:   Asthma; Eosinophilic;   COVID;   Covid-19 Interventions:   Dietary Supplement: Best Standard of Care + CARDIO;   Dietary Supplement: Best Standard of Care Sponsors:   Hofseth Biocare ASA;   KGK Science Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Cardinale F, Lombardi E, Rossi O, Bagnasco D, Bellocchi A, Menzella F Abstract INTRODUCTION: Damage to the respiratory epithelium, is often a multifactorial phenomenon where environmental and host factors may concur to determine the same effect. The risk for developing a damage in respiratory epithelium and recurrent respiratory infections may vary among individuals both in children and in adults. Preventive measures are based on strengthening the immune function, thus increasing the natural response to pathogens. Immunomodulatory agents are: i. synthetic molecules; ii. Probiotics, prebiotics, symbiotics; ...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Authors: Kim S, Jin HJ, Kim SR PMID: 32638569 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
Authors: Kim JH, Park HS, Ye YM, Shin YS, Kang HR, Chung SJ, Choi JH PMID: 32638568 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
Authors: Vultaggio A, Nencini F, Bormioli S, Vivarelli E, Dies L, Rossi O, Parronchi P, Maggi E, Matucci A Abstract Eosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis characterized by multisystemic manifestations including asthma. Mepolizumab (300 mg/4 weeks) has recently been approved for EGPA. However, real-life data are scarce and report experiences with high doses of mepolizumab intravenously administered (750 mg/4 weeks). The aim of our study was to investigate in a real-life setting whether mepolizumab in EGPA patients at low doses would enable us 1) to control asthma symptoms, 2) to obtain ...
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
Authors: Jang H, Kim M, Hong JY, Cho HJ, Kim CH, Kim YH, Sohn MH, Kim KW Abstract The mitochondrial genome encodes core catalytic peptides that affect major metabolic processes within a cell. Here, we investigated the association between mitochondrial DNA (mtDNA) variants and allergic diseases, including atopic dermatitis (AD) and asthma, alongside heteroplasmy within the mtDNA in subjects with allergic sensitization. We collected genotype data from 973 subjects with allergic sensitization, consisting of 632 children with AD, 498 children with asthma, and 481 healthy controls by extracting DNA from their blood samp...
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
CONCLUSIONS: MiR-1165-3p negatively may regulate Th2-cell differentiation by targeting IL-13 and PPM1A in allergic airway inflammation. PMID: 32638565 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
Authors: Huang R, Qin R, Hu Q, Zhu Z, Liu Y, Luo T, Li J Abstract PURPOSE: It remains unknown whether allergen-specific immunotherapy (AIT) could attenuate airway inflammatory response triggered by allergen exposure. METHODS: We performed Dermatophagoides pteronyssinus (Der-p) nasal provocation tests (NPTs) in allergic rhinitis (AR) and/or asthma patients without AIT (non-AIT), or at 16, 52, 104, or 156 weeks after Der-p AIT. Rhinitis and asthma visual analog scale (VAS; VAS of nasal symptoms [VAS-NS], VAS of asthma symptoms), the rhinoconjunctivitis quality of life questionnaire (RQLQ), nasal lavage, sputum in...
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
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