Three-Component Synthesis of Spiro[Indoline-3,4'-Pyrano[3,2-b]Pyran]-2,8'-Diones Using a One-Pot Reaction.

Three-Component Synthesis of Spiro[Indoline-3,4'-Pyrano[3,2-b]Pyran]-2,8'-Diones Using a One-Pot Reaction.
Comb Chem High Throughput Screen. 2013 Oct 27;
Authors: Rahmati A, Khalesi Z, Kenarkoohi T
Abstract
A one-pot, three-component reaction of an isatine and kojic acid with an active methylene compound such as ethyl cyanoacetate, methyl cyanoacetate and malononitrile in methanol using catalytic amount of DABCO to give 2'-amino-6'-(hydroxymethyl)-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-2,8'-diones in good to excellent yields under reflux conditions, is described.
PMID: 24164049 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - October 27, 2013 Category: Chemistry Authors: Rahmati A, Khalesi Z, Kenarkoohi T Tags: Comb Chem High Throughput Screen Source Type: research