Gut bacteria Akkermansia elicit a specific IgG response in CSF of patients with MS

MS is a chronic inflammatory disease of the CNS involving T cell and B cell responses. Recently, several studies have described modifications of specific bacterium abundances of gut microbiota in patients with remitting–relapsing MS compared with healthy individuals (see for review1). This was often associated with an increase in Akkermansia muciniphila bacteria. In experimental autoimmune encephalomyelitis, transfer of gut microbiota from patients with MS to mice induced proinflammatory responses and exacerbation of the disease, whereas microbiota from healthy volunteers (HVs) were less inflammatory.2,3 Because bacteria in the gut modulate immune responses, we assessed the antibody production against A muciniphila in patients with MS. In CSF, levels of anti-A muciniphila immunoglobulin G (IgG) were increased in patients with MS compared with controls, whereas no difference was found for levels of IgG against Escherichia coli, Fusobacterium necrophorum, Acinetobacter baumannii, Prevotella melaninogenica, and Bacteroides fragilis.

Source: Neurology Neuroimmunology and Neuroinflammation - March 1, 2020 Category: Neurology Authors: Vallino, A., Dos Santos, A., Mathe, C. V., Garcia, A., Morille, J., Dugast, E., Shah, S. P., Hery-Arnaud, G., Guilloux, C.-A., Gleeson, P. J., Monteiro, R. C., Soulillou, J.-P., Harb, J., Bigot-Corbel, E., Michel, L., Wiertlewski, S., Nicot, A. B., Laplau Tags: Autoimmune diseases, Cerebrospinal Fluid, Multiple sclerosis Clinical/Scientific Notes Source Type: research