Platelet and megakaryocyte CD40L expression in β-Thalassemic patients

β-Thalassemia is an inherited disease caused by a decrease or absence of β-globin chain synthesis and is often associated with inflammatory processes and hypercoagulation state [1,2]. It is largely accepted that platelets play a key role in inflammation and thrombosis and that CD40L is involved in both these processes; it is strongly expressed by platelets and is rapidly cleaved to generate a soluble form (sCD40L). Previous studies suggested that platelet-associated CD40L can be biochemically modulated during megakaryocyte (MK) differentiation [3,4].

Source: Thrombosis Research - March 1, 2020 Category: Hematology Authors: Ornella Morsilli, Raffaella Guerriero, Valentina Lulli, Laura Maffei, Luca Pasquini, Fabio Maria Pulcinelli, Francesco Sorrentino, Marco Gabbianelli Tags: Letter to the Editors-in-Chief Source Type: research