Comparative study of spironolactone and eplerenone in management of ascites in patients of cirrhosis of liver

Introduction: The present study was conducted to compare the efficacy and side effects of Spironolactone and Eplerenone in management of ascites due to liver cirrhosis. Materials and methods: 105 patients of ascites with liver cirrhosis were randomized into three groups of 35 patients each. Group I was given Spironolactone 100 mg, group II was given Eplerenone 100 mg and group III was given Eplerenone 50 mg. All patients were put on salt-restricted diet (less than or equal to 2 g of sodium) and no loop diuretics were used. Patients were followed after 7 days from the baseline and then biweekly for the period of three months and serial measurements of weight, abdominal girth and incidence of side effects especially gynecomastia, mastalgia, hyperkalemia were recorded. Results were compared. Patients having Child–Turcotte–Pugh score-C, massive ascites, hepatic encephalopathy, Hepatorenal syndrome and ascites due to cardiac, renal, malignant causes were excluded. Observations: Difference in mean weight reduction was non significant (P = 0.964) in group I and group II whereas the difference was significant when comparison was made between Group I and III; and Group II and III (P =
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

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Publication date: Available online 3 June 2020Source: Food Quality and PreferenceAuthor(s): Gastón Ares, Lucía Antúnez, Tobias Otterbring, María Rosa Curutchet, Luis Galicia, Ximena Moratorio, Isabel Bove
Source: Food Quality and Preference - Category: Food Science Source Type: research
CONCLUSION: The results support our hypothesis - that sensory innervation has an impact on the inorganic component of the mandibular bone. PMID: 32481243 [PubMed - in process]
Source: Journal of Musculoskeletal Neuronal Interactions - Category: Neurology Tags: J Musculoskelet Neuronal Interact Source Type: research
Publication date: Available online 3 June 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Waleed M. Arafa, Guilherme M. Klafke, Jason P. Tidwell, Adalberto A. Pérez de León, Maria Esteve-Gassent
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Conclusion: The presence of two different nematodes in the equids coprolites provide clues of the burden of helminths infection on working animal at the Sassanid time and demonstrates the appropriate preservation condition of biological remains in the ancient salt mine of Chehrabad as well. PMID: 32489382 [PubMed]
Source: Iranian Journal of Parasitology - Category: Parasitology Tags: Iran J Parasitol Source Type: research
ConclusionThis large retrospective cohort study suggests that patients who used PPIs are at higher risk of developing gynecomastia. Clinicians may want to convey this information to male patients who require long ‐term PPI therapy.This article is protected by copyright. All rights reserved.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Brief Report Source Type: research
Conclusions Breast tissue diameter is a simple and reliable quantitative tool for the assessment of gynecomastia. This method provides the ability to determine the incidence of gynecomastia by age in the general population. Radiological gynecomastia should be defined as 22 mm, 28 mm, or 36 mm (90th, 95th, and 97.5th percentiles, respectively). Radiological gynecomastia is not associated with obesity, but is associated with cirrhosis and dialysis.
Source: Academic Radiology - Category: Radiology Source Type: research
Background and aim Gonadal function is affected significantly in male patients with cirrhosis. The aim of this study was to assess the level of sex hormones in male patients with hepatitis C virus-related liver cirrhosis and its reflection on clinical presentation. Patients and methods This cross-sectional study was carried out on 40 consecutive male patients with hepatitis C virus-related cirrhosis of Child–Pugh class C in addition to 20 age-matched healthy male participants (control group). All were subjected to an assay of serum hormonal levels: total and free testosterone, estradiol (E2), sex hormone-binding...
Source: Egyptian Liver Journal - Category: Gastroenterology Tags: Original articles Source Type: research
Abstract Primary breast lymphoma is a rare type of non-Hodgkin lymphoma and usually affects women, although a few cases have been reported in men. Chemotherapy and radiation therapy, or a combination of both, are frequently administered for treatment of primary breast lymphoma, as local control by surgical resection is poor. No standard therapy has been established, and the optimal radiation dose and irradiation field for male patients are unknown. The present report describes a 75-year-old man with bilateral cirrhosis-induced gynecomastia who was diagnosed with primary breast lymphoma; specifically, diffuse large...
Source: International Journal of Hematology - Category: Hematology Authors: Tags: Int J Hematol Source Type: research
Is it b/c of the decreased synthesis of SHBG? Liver dysfunction leading to low SHBG synthesis--> Low SHBG conc --> Increases free estrogen --> causes spider nevi, gynecomastia, testicular trophy???
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums
Authors: Dinis-Oliveira RJ, Magalhaes T, Queiros O, Proenca JB, Moreira R, de Lourdes Bastos M, Carvalho F Abstract Ethanol is the most abused psychoactive substance. Accordingly to World Health Organization ethanol ranks among the top five risk factors for disease, disability and death (3.3 million/year) throughout the world. This manuscript highlights and critically analyses clinical and forensic signs related to hepatoxicity of ethanol that may lead to suspected of abuse. Namely, steatosis, jaundice, cirrhosis, hemorrhoids, esophageal varices caput medusae, ascites, petechiae, ecchymoses, splenomegaly, hemochrom...
Source: Current Drug Abuse Reviews - Category: Addiction Tags: Curr Drug Abuse Rev Source Type: research
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