Somatic mRNA Analysis of BRCA1 Splice Variants Provides a Direct Theranostic Impact on PARP Inhibitors

ConclusionIn a break from purely in silico approaches, we propose a simple and rapid pretherapeutic functional analysis of somaticBRCA1 variants potentially involved in splicing alterations. This approach will allow more ovarian cancer patients to benefit from new therapies targeting PARP.

http://link.springer.com/10.1007/s40291-020-00452-z

Source: Molecular Diagnosis and Therapy - March 1, 2020 Category: Molecular Biology Source Type: research