Morphine-3-glucuronide causes antinociceptive cross-tolerance to morphine and increases spinal substance P expression.

This study shows that chronic intrathecal M3G sensitises animals to mechanical stimulation and elevates substance P levels in the nociceptive laminae of the spinal cord. Chronic M3G also induces antinociceptive cross-tolerance to morphine. Thus, chronic M3G exposure might contribute to morphine-induced tolerance and opioid-induced hyperalgesia.
PMID: 32112778 [PubMed - as supplied by publisher]

Source: European Journal of Pharmacology - February 25, 2020 Category: Drugs & Pharmacology Authors: Blomqvist KJ, Viisanen H, Ahlström FHG, Jokinen V, Sidorova YA, Suleymanova I, Rauhala PV, Kalso EA, Lilius TO Tags: Eur J Pharmacol Source Type: research