Aortic Stiffness Is Associated With Left Ventricular Diastolic Dysfunction in Systemic Lupus Erythematosus: A Controlled Transesophageal Echocardiographic Study

Abstract BackgroundAortic stiffness and left ventricular (LV) diastolic dysfunction are common and associated with increased morbidity and mortality in systemic lupus erythematosus (SLE). HypothesisIn SLE, aortic stiffness and LV diastolic dysfunction may be associated. MethodsThis 6‐year‐duration, cross‐sectional, and controlled study was conducted in 76 SLE patients (69 women; mean age, 37 ± 12 years) and 26 age‐ and sex‐matched healthy controls. All subjects underwent clinical and laboratory evaluations and transesophageal echocardiography (TEE) to assess LV diastolic function and stiffness of the descending thoracic aorta using the pressure‐strain elastic modulus (PSEM). To validate results using PSEM, aortic strain, stiffness, and distensibility were assessed. ResultsPatients as compared with controls had higher PSEM (8.14 ± 4.25 vs 5.97 ± 2.31 U, P
Source: Clinical Cardiology - Category: Cardiology Authors: Tags: Clinical Investigation Source Type: research

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In this study, the outer membrane from E. coli was isolated and used to produce OM particles with a diameter of approximately 100 nm. These prepared OM particles were applied in a thermophoretic immunoassay. First, outer membrane (OM) particles with lipopolysaccharides (LPS) and anti-LPS antibodies were used as a model to demonstrate proof of concept and the difference in E. coli thermophoresis was explained by the changes in the molecular surface area (A) and effective charge (σeff). The hydrodynamic size of the molecules was measured as a changing parameter, molecular surface area (A), by dynamic laser scattering...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Corrigendum to "Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-Analysis". Dis Markers. 2020;2020:5943216 Authors: Lee JM, Kronbichler A, Park SJ, Kim SH, Han KH, Kang HG, Ha IS, Cheong HI, Kim KH, Kim G, Kim DS, Chae HW, Lee CH, Lee KH, Shin JI Abstract [This corrects the article DOI: 10.1155/2019/9796735.]. PMID: 32082435 [PubMed - in process]
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
ConclusionsAnti-DFS70 autoantibodies might be considered a biomarker to differentiate patients with SLE from ANA-positive individuals without autoimmune diseases.Key Points:• In a Latin American cohort, the anti-DFS70 was higher in individuals without autoimmune diseases compared with that in patients with SLE.• The anti-DFS70 might have utility as a biomarker of exclusion in patients with non-specific clinical signs of AARDs.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
This article is categorized under: Biological Mechanisms> Metabolism Translational, Genomic, and Systems Medicine> Translational Medicine Physiology> Mammalian Physiology in Health and Disease
Source: Wiley Interdisciplinary Reviews: Systems Biology and Medicine - Category: Biomedical Science Authors: Tags: ADVANCED REVIEW Source Type: research
FRIDAY, Feb. 21, 2020 -- Taking their medications as prescribed significantly lowers lupus patients'risk of developing diabetes, a new study finds. Type 2 diabetes is a common complication of lupus, an autoimmune disease that can cause damaging...
Source: - Daily MedNews - Category: General Medicine Source Type: news
FRIDAY, Feb. 21, 2020 -- Socioeconomic position is inversely associated with standardized incidence of lupus nephritis and antineutrophil cytoplasmic antibody-related glomerulonephritis (ANCA-GN), according to a study published online Feb. 20 in the...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
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Source: The American Journal of Dermatopathology - Category: Pathology Tags: Brief Report Source Type: research
Authors: Ingawale DK, Mandlik SK Abstract Inflammation is a physiological intrinsic host response to injury meant for removal of noxious stimuli and maintenance of homeostasis. It is a defensive body mechanism that involves immune cells, blood vessels and molecular mediators of inflammation. Glucocorticoids (GCs) are steroidal hormones responsible for regulation of homeostatic and metabolic functions of body. Synthetic GCs are the most useful anti-inflammatory drugs used for the treatment of chronic inflammatory diseases such as asthma, chronic obstructive pulmonary disease (COPD), allergies, multiple sclerosis, te...
Source: Immunopharmacology and Immunotoxicology - Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research
This study was conducted to investigate the association between common single-nucleotide polymorphisms (SNPs) in the MK and PTN gene and SLE susceptibility. A total of 989 subjects (496 SLE patients and 493 healthy controls) were included and genotyped for three MK SNPs and seven PTN SNPs in using improved multiple ligase detection reaction (iMLDR). Results have demonstrated no significant differences for genotype and allele frequencies in all 10 SNPs between SLE patients and healthy controls. Case-only analysis in SLE revealed that, in MK gene, the genotype frequency of AA/AG (rs35324223) was significantly lower in patien...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Ronnie and colleagues reported a case of a 10-year-old female with a history of systemic lupus erythematosus (SLE) complicated by hypertension and cardiomyopathy secondary to lupus who presented to the emergency department with a history of vision loss and headache [1]. The authors diagnosed the patient with posterior reversible encephalopathy syndrome (PRES). Although interesting, the diagnostic criteria for PRES was not met.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
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