Prion protein — mediator of toxicity in multiple proteinopathies

Nature Reviews Neurology, Published online: 02 March 2020; doi:10.1038/s41582-020-0332-8A new study shows that interactions of the cellular prion protein with amyloid-β, tau and α-synuclein oligomers are important in mediating the toxicity of these proteins in Alzheimer disease and Parkinson disease. The findings suggest a shared pathway that could be a therapeutic target common to multiple neurodegenerative diseases.

Source: Nature Reviews Neurology - March 1, 2020 Category: Neurology Authors: Jacob I. Ayers Stanley B. Prusiner Source Type: research