18F-Sodium Fluoride (NaF) Imaging on Ultra-High-Resolution Positron Emission Scanner: Example of Textitis.

We report a case of 26-year-old woman with left breast cancer referred for 18F-NaF PET-CT. She is complaining of right thumb and wrist pain. Findings are negative for bone secondaries. Dedicated hands views are acquired on positron emission scanner which shows focal uptake at 1st carpometacarpcal and 2nd metacarpophalangeal joints. Findings are likely due to active arthritic changes due to repetitive strain injury caused by excess text messaging (textitis). PMID: 32111663 [PubMed - as supplied by publisher]
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research

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Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00864H, CommunicationYoan Chevalier, Yvette Lock Toy Ki, Christian Herrero, Didier Le Nouen, Jean-Pierre Mahy, Jean-Philippe Goddard, Fr édéric Avenier The elusive flavin semiquinone intermediate found in flavoproteins such as cryptochromes has been obtained in aqueous solution by single electron reduction of the natural FMN cofactor using sodium ascorbate. This... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
ConclusionThis study identified the most accurate and reliable machine learning methods, which could enhance the application of radiomics methods in the precision of diagnosis of NPC.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
ConclusionsThe results demonstrate that even subtle changes in vessel morphology can be noninvasively quantified. This is of great interest for AD, but also to other models of neurodegenerative diseases involving macrovascular dysfunction.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
ConclusionsThe new PET radiotracer [18F]AF78 demonstrated high affinity for NET and favourable biodistribution in rats. A structure-activity relationship between radiotracer structures and affinity for NET was revealed, which may serve as the basis for the further design of NET targeting radiotracers with favourable features.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
ConclusionsUnlike [18F]FDG, [18F]BODIPY 1 showed prominent accumulation in BAT under both inactive and stimulated status. [18F]BODIPY 1 may serve as a valuable BAT PET agent to possibly assess BAT mitochondria density, thus BAT thermogenic capacity after further evaluation.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
ConclusionsHypoxia modulation may play a role in nal-IRI ’s mechanism of action. Nal-IRI demonstrated greater anti-tumor activity in the more aggressive and hypoxic tumor model. Furthermore, hypoxia imaging provided early prediction of treatment response.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
AbstractThe current utilization of positron emission tomography (PET) imaging is limited due to the high costs associated with production facility start-up and operations; subsequently, there has been a movement towards microfluidic synthesis of radiolabeled imaging pharmaceuticals (tracers). In this review, we summarize the current status of microfluidic radiosynthesis units for producing fluorine-18 labeled PET imaging tracers, including a discussion of the relative strengths and weaknesses of such devices. In addition, we provide a brief overview of the radiotracers that have been produced using microfluidic devices to ...
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
AbstractPurposeTo investigate and validate the potential role of a radiomics signature in predicting the side-specific probability of extracapsular extension (ECE) of prostate cancer (PCa).ProceduresThe preoperative magnetic resonance imaging data of 238 prostatic samples from 119 enrolled PCa patients were retrospectively assessed. The samples with were randomized in a two-to-one ratio into training (n = 74) and validation (n = 45) datasets. The radiomics features were derived from T2-weighted images (T2WIs). The optimal radiomics features were identified from the least absolute shrinkage and s...
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
ConclusionsIntegrated [68Ga]PSMA-11 PET/MRI provides a similarly high diagnostic performance for localization of recurrent PC as PET/CT. For the detection of local recurrences [68Ga]PSMA-11 PET/MRI is superior compared with [68Ga]PSMA-11 PET/CT.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
AbstractPurposeExisting clinical or microbiological scores are not sensitive enough to obtain prompt identification of patients at risk of complicatedClostridium difficile infection (CDI). Our aim was to use a CDI animal model to evaluate 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography ([18F]FDG-PET) as a marker of severe course of infection.ProceduresCDI was induced with cefoperazone for 10  days followed by clindamycin 1 day beforeC. difficile inoculation. Mice were divided into wild type (n = 6), antibiotic without infection (ACn = 4), h001-infected (n = 5...
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
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