Curcumin Suppresses Apoptosis and Inflammation in Hypoxia/Reperfusion-Exposed Neurons via Wnt Signaling Pathway.

CONCLUSIONS Curcumin exerted neuro-protective effects against H/R-induced neuron apoptosis and inflammation by inhibiting activation of the Wnt/JNK1 signaling pathway. PMID: 32107363 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research

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Phys. Chem. Chem. Phys., 2020, Advance Article DOI: 10.1039/D0CP01952F, PaperPeng Liu, Wenqi Hao, Xihui Bian, Donghai Mei Understanding movements within molecular machines is the prerequisite of tailoring its structure to achieve specific functions. With the aid of molecular dynamics simulations and enhanced sampling methods, movements within the foldaxane have been revealed. Movements,viz., translocation, rotation, tilt, shrinkage, and swelling, have been identified and investigated in detail. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Ro...
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.0c05626
Source: ACS Applied Materials and Interfaces - Category: Materials Science Authors: Source Type: research
Chromosomal translocations are an integral part of cancer pathogenesis. In hematological malignancies, they play an outsized role and, as exemplified by the t(9;22) /BCR-ABL fusion, and t(15;17) /PML-RAR α fusion, these abnormalities can inform the disease biology, diagnosis and the development of rational therapies [1]. In mature B-cell malignancies, chromosomal translocation often lead to the juxtaposition of a “target” gene locus to the regulatory regions of the immunoglobulin heavy (IGH) or light chain loci [2].
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Tags: Original article Source Type: research
We experienced a patient who had four lung cancers with different pathological features, with the most advanced being diagnosed as pStage IIA. A month after the resection, the original lung cancer had metastasized to the lung and to the liver. Of the original lung cancers that were resected, the biggest adenocarcinoma of S3 showed 50 × 31 × 17 mm (invasion 50 mm) and pT2bN0M0 (pStage IIA) with epidermal growth factor receptor (EGFR) mutation (–) and anaplastic lymphoma kinase (ALK) translocation (–), but expression of programmed death ligand 1 (PD-L1) (+) tumor proportion score (TPS) 80%. The pleomo...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionThe affected siblings have similar phenotype, including ID, short stature, and microcephaly. Their mother had a history of seven first ‐trimester miscarriages and one elective termination because of multiple malformations. This abnormal karyotype was also thought to be responsible for the mother's recurrent miscarriage. WES in combination with CNV‐seq analysis is very helpful for identification of the genetic causes of ID witho ut positive karyotype findings.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractOsteoarthritis (OA), in which inflammation plays a crucial role, is the most common joint disease characterized by cartilage degradation. Neferine (Nef), a dibenzyl isoquinoline alkaloid, has shown its anti-inflammatory effects on other inflammatory diseases. Therefore, we hypothesized that Nef might also have an anti-inflammatory effect on OA and explored its effect on IL-1 β-treated rat chondrocytes. Sprague Dawley (SD) rat chondrocytes were stimulated with IL-1β (10 ng/ml) and Nef (1, 5, and 10 μM) or IL-1β (10 ng/ml) alone for 24 h. Expression of inducible nitric oxide synt...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
Publication date: Available online 30 May 2020Source: Journal of Hazardous MaterialsAuthor(s): Jun Ge, Haixin Wang, Jiayu Lin, Shengke Tian, Jianqi Zhao, Xianyong Lin, Lingli Lu
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
Abstract Deltex-3-like (DTX3L), an E3 ligase, which is also known as B-lymphoma and BAL-associated protein (BBAP), is a member of the Deltex (DTX) family and was originally identified as a binding partner of diphtheria-toxin-like ADP-ribosyltransferase-9 (ARTD9). The present study found that DTX3L and ARTD9 were upregulated in synovial tissues obtained from rheumatoid arthritis (RA) patients compared with those from the controls. Healthy synovial tissues were obtained by arthroscopic biopsy from patients with meniscus injury (n = 10 samples) without a history of RA in the Orthopedic Department of the...
Source: Tissue and Cell - Category: Cytology Authors: Tags: Tissue Cell Source Type: research
FUS is a nucleic acid binding protein that, when mutated, cause a subset of familial amyotrophic lateral sclerosis (ALS). Expression of FUS in yeast recapitulates several pathological features of the disease-causing mutant proteins, including nuclear to cytoplasmic translocation, formation of cytoplasmic inclusions, and cytotoxicity. Genetic screens using the yeast model of FUS have identified yeast genes and their corresponding human homologs suppressing FUS induced toxicity in yeast, neurons and animal models. To expand the search for human suppressor genes of FUS induced toxicity, we carried out a genome-scale genetic s...
Source: G3: Genes Genomes Genetics - Category: Genetics & Stem Cells Authors: Tags: Mutant Screen Report Source Type: research
Hematopoietic cell transplantation (HCT) is an established treatment for several hematologic and solid malignancies. Patients undergoing HCT have prolonged neutropenia after transplantation due to conditioning with high-dose chemotherapy with or without total body irradiation. Although gastrointestinal endoscopy is indicated for the diagnosis and treatment of HCT-related complications that can present during the engraftment period such as acute graft versus host disease, gastrointestinal cytomegalovirus infection, and hemorrhage, it is relatively contraindicated due to concern for translocation of enteric pathogens during the procedure.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Oral abstracts Source Type: research
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