PI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma

Glucocorticoid (GC) insensitivity is an important feature of severe and fatal asthma. Oxidative stress can induce phosphoinositide-3-kinase (PI3K) activation, contributing to the development of GC insensitivit...

Source: Clinical and Translational Medicine - February 28, 2020 Category: Internal Medicine Authors: Jing Bi, Zhihui Min, Honglei Yuan, Zhilong Jiang, Ruolin Mao, Tao Zhu, Chunfang Liu, Yuzhen Zeng, Juan Song, Chunling Du and Zhihong Chen Tags: Research Source Type: research