RSV Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells.

CONCLUSIONS: Pneumovirus infection induces AEC necroptosis. Inhibition of necroptosis may be a viable strategy to limit the severity of viral bronchiolitis and break its nexus with asthma. PMID: 32105156 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research

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CONCLUSION: The design results revealed that an optimum exposure of 1:2 of isopropanol: formaldehyde vapours for sixty minutes resulted in desired release of second pulse of dose after a predetermined lag time of 5 hours as desired. '3Cap' system was successful in achieving floating and pulsed release of hypertensive drug opening a 'new lease of life' to the existing drug molecule. PMID: 32484113 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research
Publication date: Available online 2 June 2020Source: Journal of Molecular BiologyAuthor(s): Theresa Kriegler, Sven Lang, Luigi Notari, Tara Hessa
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
There is a strong correlation between dysregulation of the gastrointestinal microbiota and development of allergic diseases. The most prevalent therapies for relieving asthma symptoms are associated with serious side effects, and therefore novel approaches are needed. Our objective was to elucidate whether oral administration of Lactobacillus rhamnosus GG (LGG) as a probiotic or turmeric powder (TP) as a prebiotic or both as a synbiotic mitigate allergic inflammation including lung function, airway inflammatory cell infiltration, Th2 cytokines/chemokine in a murine model of house dust mite (HDM)-induced asthma. BALB/c mice...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 2 June 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jaya Muneswarao, Mohamed Azmi Hassali, Baharudin Ibrahim, Bandana Saini, Irfhan Ali Hyder Ali, Anees ur Rehman, Ashutosh Kumar Verma, Atta Abbas Naqvi, Rabia Hussain
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
In conclusion, because the inhalers used by elderly patients are in poor hygienic conditions, we must give cleaning instructions accordingly. We believe that it is necessary to give proper medical instructions along with instructions on the cleaning method with dry cloth. PMID: 32475929 [PubMed - in process]
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
Phys. Chem. Chem. Phys., 2020, Advance Article DOI: 10.1039/D0CP01952F, PaperPeng Liu, Wenqi Hao, Xihui Bian, Donghai Mei Understanding movements within molecular machines is the prerequisite of tailoring its structure to achieve specific functions. With the aid of molecular dynamics simulations and enhanced sampling methods, movements within the foldaxane have been revealed. Movements,viz., translocation, rotation, tilt, shrinkage, and swelling, have been identified and investigated in detail. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Ro...
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
Conclusions: This nationwide ecologic study of older adults suggests that residence in areas with more construction and manufacturing sites is associated with increased ARDS risk.
Source: Epidemiology - Category: Epidemiology Tags: Environmental Epidemiology Source Type: research
Conclusion: The prevalence of respiratory symptoms and corresponding diagnoses varied between and within the countries. The proportion reporting a diagnosis of obstructive airway disease among individuals with respiratory symptoms varied, indicating differences in diagnostic patterns both between areas and by sex. PMID: 32475292 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Conclusions: Mindfulness interventions could increase psychological resources in situations related to asthma and COPD symptoms. More randomized control trials are needed. PMID: 32475186 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
MP-AzeFlu is relatively new a pharmaceutical drug used in the treatment of allergic rhinitis. It is comprised of azelastine hydrochloride (AZE), a potent histamine-H1-receptor antagonist and fluticasone propio...
Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Letter to the editor Source Type: research
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