Nicotinamide activates latent HIV-1 ex vivo in ART suppressed individuals, revealing higher potency than the association of two methyltransferase inhibitors, chaetocin and BIX01294.

CONCLUSION: NAM alone was more potent HIV-1 activator of than combination of MTIs, with potential of clinical use.
PMID: 32105620 [PubMed - as supplied by publisher]

Source: Braz J Infect Dis - February 23, 2020 Category: Infectious Diseases Authors: Samer S, Arif MS, Giron LB, Zukurov JPL, Hunter J, Santillo BT, Namiyama G, Galinskas J, Komninakis SV, Oshiro TM, Sucupira MC, Janini LM, Diaz RS Tags: Braz J Infect Dis Source Type: research