First-of-its-kind global collaboration launched to develop transformative treatment regimens for tuberculosis

27 February 2020 – Today a consortium of philanthropic, non-profit and private sector organizations launched a collaboration that aims to accelerate the development of novel “pan-TB” drug regimens for the treatment of tuberculosis (TB) that are ready for phase 3 development. The regimens will be designed to have little to no drug resistance and an acceptable safety profile, and be better-tolerated, shorter in duration and simpler to use than existing options. Such regimens are intended to be a central component of efforts to address the current complexities and challenges of TB treatment.The members of the Project to Accelerate New Treatments for Tuberculosis (PAN-TB collaboration) – Evotec, GSK, Johnson &Johnson, Otsuka Pharmaceutical Co., Ltd., based in Japan, the Bill &Melinda Gates Medical Research Institute and the Bill &Melinda Gates Foundation – have committed to leveraging their unique assets, resources and scientific expertise to advance the development of novel regimens. “Current tools are insufficient for accelerating and sustaining global progress against TB,” said Trevor Mundel, President of Global Health at the Bill &Melinda Gates Foundation. “Innovative partnerships, such as the PAN-TB collaboration, are urgently needed to develop new drugs and treatment regimens that can address TB and advance progress towards achieving global elimination TB goals.”TB causes more deaths globally than any oth...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news

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NEW BRUNSWICK, NJ, May 27, 2020 — The Janssen Pharmaceutical Companies of Johnson &Johnson today announced that the U.S. Food and Drug Administration (FDA) has granted approval for a new pediatric formulation of SIRTURO® (bedaquiline). SIRTURO® is now indicated for use as part of combination therapy in the treatment of adult and pediatric patients (5 years and older and weighing at least 15 kg) with pulmonary multidrug-resistant tuberculosis (MDR‑TB). In the U.S., the medicine should be reserved for use when an effective treatment regimen cannot otherwise be provided. This indication received accelera...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Chen Antimicrobial resistance (AMR) has become a global threat to not only public health impacts but also clinical and economic outcomes. During the past decades, there have been many studies focusing on surveillance, mechanisms, and diagnostics of AMR in infectious diseases but the impacts on public health, clinical and economic outcomes due to emergence of these AMRs are rarely studied and reported. This review was aimed to summarize the findings from published studies to report the outcome impacts due to AMR of malaria, tuberculosis and HIV and briefly discuss the implications for application to other infectious dis...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, he pointed to the “profound” challenges we face, saying: “I am confident that if we continue and strengthen international co-operation and seize the opportunities already available, while creating even more opportunities, we can overcome them – together”.   ‘A political choice’ Universal health coverage means all people regardless of their ability to pay, having access to the health care they need, when and where they need it, without facing financial hardship. Congratulating world leaders, Tedros Adhanom Ghebreyesus, Director-General at the World Health Or...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Development & Aid Global Headlines Health Human Rights Source Type: news
(CNN) — From climate change to superbugs, the World Health Organization has laid out 10 big threats to our global health in 2019. And unless these threats get addressed, millions of lives will be in jeopardy. Here’s a snapshot of 10 urgent health issues, according to the United Nations’ public health agency: Not vaccinating when you can One of the most controversial recent health topics in the US is now an international concern. “Vaccine hesitancy — the reluctance or refusal to vaccinate despite the availability of vaccines — threatens to reverse progress made in tackling vaccine-prevent...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Local TV Source Type: news
We’re excited to share the topic and questions for this week’s #HITsm chat happening Friday, 11/30 at Noon ET (9 AM PT). This week’s chat will be hosted by Vanessa Carter (@_FaceSA) on the topic of “The Global Impact of Health IT”. Global health pandemics like antibiotic and antimicrobial resistance are among the most critical issues to tackle and in future will require robust, harmonious data surveillance systems along with mass co-operation between the animal, human and environmental health sectors across every country [1]. This is known as One Health [2]. WHO initiatives like GLAS...
Source: EMR and HIPAA - Category: Information Technology Authors: Tags: #HITsm Healthcare Healthcare AI HealthCare IT #HITsm Topics Antibiotic Resistance GLASS Global Antimicrobial Resistance Surveillance System Global Health One Health Vanessa Carter Source Type: blogs
150 years after Semmelweis advised fellow physicians to sanitize their hands to mitigate the effect of infections, the maintenance of hygiene is still a widespread problem in hospitals and the source of healthcare-associated infections. Now, technological solutions line up against microorganisms, bacteria, and fungi. Here are a few examples. 1 in 9 in-patients will die due to infection According to the US Center for Disease Control, studies show that on average, healthcare providers clean their hands less than half of the times they should. This significantly contributes to the spread of healthcare-associated infections (H...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Healthcare Design Medical Professionals Policy Makers clean digital digital health future HAI healthcare-associated infection hygiene Medicine robot robotics sensors technology trackers wearable Source Type: blogs
Nigeria Centre for Disease Control. 11/2017 This 158-page situation analysis report is based on the current situation for antimicrobial use and resistance in Nigeria, and provides recommendations for immediate and long-term goals. It discusses how much of the disease burden in Nigeria comes from AIDS, tuberculosis, and malaria. The country also suffers considerable burden from systemic infections, including HIV, bacteremia, and meningitis. There are, as yet, no available studies outlining the full burden of antimicrobial resistance and its health and economic impact on Nigerians. (PDF)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Authors: Source Type: news
By Grace VirtueTAORMINA, Italy, May 25 2017 (IPS)The G7 Summit, held annually among the leaders of the world’s most powerful economies (Canada, France, Germany, Italy, Japan, the United Kingdom, the United States, and the EU), plays an important role in shaping responses to global challenges—theoretically at least. The format of the Summit continues to be modeled off the first one, held in 1975 when French President Valéry Giscard d’Estaing invited his counterparts to an informal meeting in Rambouillet to discuss the economic crisis triggered by the oil shock of 1973–1974. Leaders adopt a rel...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Aid Armed Conflicts Civil Society Crime & Justice Development & Aid Economy & Trade Featured Financial Crisis Global Global Governance Headlines Health Human Rights Migration & Refugees Poverty & SDGs Trade & Investment Source Type: news
On Sept 21, 2016, the United Nations called a meeting on antimicrobial resistance with policymakers to address antimicrobial resistance comprehensively and multisectorally.1 An estimated 700  000 people around the world die each year from drug-resistant strains of common bacterial infections, tuberculosis, and malaria,2 and total global deaths caused by antibiotic-resistant infections are estimated to reach 10 million per year by 2050, with economic losses exceeding US$100 trillion.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Correspondence Source Type: research
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