Pathophysiological role of calcitonin gene-related peptide (CGRP) in migraine and cluster headache.

[Pathophysiological role of calcitonin gene-related peptide (CGRP) in migraine and cluster headache]. Schmerz. 2020 Feb 26;: Authors: Meßlinger K Abstract Calcitonin gene-related peptide (CGRP) is released from trigeminal afferents during migraine and cluster headache attacks and can be detected in the jugular plasma. Infusion of CGRP can induce headache attacks in migraine and cluster patients. Inhibition of the CGRP signal system is therapeutic in migraine and cluster headache. CGRP is a potent dilator of intracranial arteries but does not immediately activate the trigeminal pain system. CGRP may act as a signal molecule between different cells in the trigeminal ganglion and enhances nociceptive transmission in the spinal trigeminal nucleus. Peripheral inhibition of the CGRP system reduces these actions. Outside the trigeminovascular system, CGRP is important for maintaining the perfusion of organs in critical situations, promotes growth and repair functions and is an immunomodulatory factor. These actions should be considered when the CGRP system is suppressed for a long time. PMID: 32103345 [PubMed - as supplied by publisher]
Source: Schmerz - Category: Anesthesiology Authors: Tags: Schmerz Source Type: research

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AbstractPurpose of ReviewThe purpose of this manuscript is to provide a comprehensive review of postdural puncture headache (PDPH) with a focus on epidemiology, pathophysiology, treatment, and prophylaxis.Recent FindingsPDPH is an adverse iatrogenic complication of neuraxial anesthesia that occurs following inadvertent puncture of the dura after epidural or spinal anesthesia. The overall incidence of PDPH after neuraxial procedures varies from 6 to 36%. The occurrence of PDPH can lead to increased patient morbidity, delayed discharge, and increased readmission. PDPH is a self-limiting postural headache that most often will...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
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Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research
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Source: A&A Case Reports - Category: Anesthesiology Tags: Case Reports Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Neurological Sciences - Category: Neurology Source Type: research
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Source: Indian Journal of Anaesthesia - Category: Anesthesiology Authors: Source Type: research
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Source: The Journal of Headache and Pain - Category: Neurology Source Type: research
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