N-terminal region of Helicobacter pylori CagA induces IL-8 production in gastric epithelial cells via the β1 integrin receptor.

Conclusion. Residues 303-456 of the N-terminal region of CagA induce IL-8 production via a CagA303-456-ITGB1-p38-IL-8 pathway, and ERK1/2 is also involved in the release of IL-8. Extracellular CagA might induce IL-8 production before translocation into AGS cells.
PMID: 32100714 [PubMed - as supplied by publisher]

Source: Journal of Medical Microbiology - February 24, 2020 Category: Microbiology Authors: Zeng B, Chen C, Yi Q, Zhang X, Wu X, Zheng S, Li N, She F Tags: J Med Microbiol Source Type: research