Glucose ingestion in cystic fibrosis induces severe redox imbalance: A potential role in diabetes

Cystic fibrosis (CF) is classically characterized by a progressive obstructive pulmonary disease and pancreatic exocrine insufficiency [1]. It is primarily the progressive respiratory decline that leads to an early mortality for those with CF. There are many other co-morbidities, such as cystic fibrosis-related diabetes (CFRD), that accelerates the lung decline [1]. The onset of CFRD portends a much worse prognosis and is associated with a more rapid loss of lung function, more frequent pulmonary exacerbations and ultimately an increase in mortality due to respiratory failure [2,3].

Source: Journal of Cystic Fibrosis - February 26, 2020 Category: Respiratory Medicine Authors: William R. Hunt, Jason M. Hansen, Arlene A. Stecenko Tags: Original article Source Type: research