Neuropeptide Y Acts Directly on Cartilage Homeostasis and Exacerbates Progression of Osteoarthritis through NPY2R

In conclusion, our findings provide d the direct evidences and the crucial role of NPY in cartilage homeostasis.This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research

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Publication date: Available online 30 March 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Vidya S. Krishnan, Annemieke Aartsma-Rus, Maurice Overzier, Cathleen Lutz, Laurent Bogdanik, Miranda D. Grounds
Source: Molecular and Cellular Neuroscience - Category: Neuroscience Source Type: research
Conclusion: The current review identified strong, high-quality evidence to recommend hip muscle strengthening in the conservative management of persons with knee OA. Further research is needed to establish the underlying mechanisms for the clinical benefits.
Source: Journal of Geriatric Physical Therapy - Category: Physiotherapy Tags: Systematic Reviews Source Type: research
We want to compare mortality in heart transplant (HTx) recipients with and without Muscular Dystrophy.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (722) Source Type: research
Publication date: Available online 30 March 2020Source: Journal of Orthopaedic TranslationAuthor(s): Lawrence C.-M. Lau, Jason C.-H. Fan, Kwong-Yin Chung, Kin-Wing Cheung, Gene C.-W. Man, Yuk-Wah Hung, Carson K.-B. Kwok, Kevin K.-W. Ho, Kwok-Hing Chiu, Patrick S.-H. Yung
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
Conditions:   Osteoarthritis, Knee;   Knee Replacement Intervention:   Behavioral: Mindfulness-based Cognitive Behavioral Therapy Sponsor:   Brigham and Women's Hospital Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Gökaslan S, Demirbaş H, Özer Gökaslan Ç Abstract BACKGROUND/AIM: Multiple sclerosis (MS) is an autoimmune disease characterized by neurodegeneration or demyelination, and the relapsing?remitting phase of MS is characterized by acute exacerbation of disease activity. The most commonly used non-invasive approach to assess autonomic function is the determination of heart rate turbulence (HRT) and heart rate variability (HRV). The aim of this study was to evaluate the presence of cardiovascular autonomic dysfunction using HRT and HRV parameters determined via 24-hour Holter ECG monitorin...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Authors: Jia M, Xiong Y, Li M, Mao Q Abstract Chemotherapy is critical for the treatment of hepatocellular carcinoma (HCC). Despite the pro-apoptotic effects of corosolic acid (CA) treatment, its underlying mechanism is not completely clear. The aim of this study was to determine the molecular mechanism of CA in HCC treatment. MTT assay was used to determine the IC50 of CA. Immunoprecipitation and immunofluorescence were used to detect the interaction between and subcellular localization of Yes-associated protein (YAP) and mouse double minute 2 (MDM2). In addition, in vivo xenotransplantation was performed to asses...
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research
In conclusion, sitagliptin may have a potential inhibitory effect on GC by AMPK/YAP/melanoma‐associated antigen‐A3 pathway.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Fast signaling from vision and proprioception to muscle activation plays essential roles in quickly correcting movement. Though many studies have demonstrated modulation of the quick sensorimotor responses as depending on context in each modality, the contribution of multimodal information has not been established. Here, we examined whether state estimates contributing to stretch reflexes are represented solely by proprioceptive information or by multimodal information. Unlike previous studies, we newly found a significant stretch-reflex attenuation by the distortion and elimination of visual-feedback without any change in...
Source: eLife - Category: Biomedical Science Tags: Neuroscience Source Type: research
In conclusion, exogenous Mo can effectively reduce Cd toxicity to rape and the optimal Mo concentration was 100 mg/kg under the experimental conditions.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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