The enhancement of TNF- α on TTX resistant NaV current in muscle sensory neurons after femoral artery occlusion.

In conclusion, Our data suggest that NaV1.8 is engaged in the role of TNF-α in amplifying muscle afferent inputs as the hindlimb muscles are ischemic; and p38-MAPK, JNK and ERK pathways are likely necessary to mediate the effects of TNF-α. PMID: 32101460 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research