Data for Beta-Blockade in ACLS – A Trial Sequential Analysis

The Advanced Cardiac Life Support algorithm for ventricular fibrillation (VF) and pulseless ventricular tachycardia (pVT) includes adrenaline (epinephrine).1 Through its peripherally vasoconstrictive alpha-adrenergic effect, blood flow is redirected centrally, improving coronary perfusion. Adrenaline ’s beta-adrenergic effect however, may be harmful. It increases myocardial sensitivity to arrhythmias, potentially leading to cardiovascular collapse from refractory pVT/VF.2,3 Therefore, there is a need to investigate potential therapies that may counteract adrenaline’s deleterious effects.
Source: Resuscitation - Category: Emergency Medicine Authors: Tags: Letter to the Editor Source Type: research