Ten ‐Gram‐Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis

In this study, a ten ‐gram‐scale facile method is developed to synthesize organogadolinium complex nanoparticles (i.e., reductive bovine serum albumin stabilized Gd‐salicylate nanoparticles, GdSalNPs‐rBSA) with highr1 value of 19.51 mm−1 s−1 and very lowr2/r1 ratio of 1.21 (B0 = 1.5 T) for high ‐contrastT1‐weighted MRI of tumors. The GdSalNPs‐rBSA nanoparticles possess more advantages including low synthesis cost (≈0.54 USD per g), long in vivo circulation time (t1/2 = 6.13 h), almost no Gd3+ release, and excellent biosafety. Moreover, the GdSalNPs ‐rBSA nanoparticles demonstrate excellent in vivo MRI contrast enhancement (signal‐to‐noise ratio (ΔSNR) ≈ 220%) for tumor diagnosis.

Source: Small - February 28, 2020 Category: Nanotechnology Authors: Zhenni Wei, Zhenqi Jiang, Chunshu Pan, Jianbi Xia, Kaiwei Xu, Ting Xue, Bo Yuan, Ozioma Udochukwu Akakuru, Chengjie Zhu, Guilong Zhang, Zheng Mao, Xiaozhong Qiu, Aiguo Wu, Zheyu Shen Tags: Full Paper Source Type: research