Intelligent Nanocomposites with Intrinsic Blood –Brain‐Barrier Crossing Ability Designed for Highly Specific MR Imaging and Sonodynamic Therapy of Glioblastoma

A holo ‐transferrin (holo‐Tf)–based nanoplatform is constructed through in situ growth of MnO2 into holo ‐Tf followed by conjugation of protoporphyrin (ppIX). This nanoplatform (MnO2@Tf ‐ppIX, abbreviated as TMP) can efficiently traverse the blood–brain barrier (BBB), realizing highly specific MR imaging of the glioblastoma region. Under ultrasound (US) irradiation, sonodynamic therapy (SDT) is achieved to evidently suppress the tumor growth. AbstractThe blood –brain barrier (BBB) is the most important obstacle to improving the clinical outcomes of diagnosis and therapy of glioblastoma. Thus, the development of a novel nanoplatform that can efficiently traverse the BBB and achieve both precise diagnosis and therapy is of great importance. Herein, an int elligent nanoplatform based on holo‐transferrin (holo‐Tf) with in situ growth of MnO2 nanocrystals is constructed via a reformative mild biomineralization process. Furthermore, protoporphyrin (ppIX), acting as a sonosensitizer, is then conjugated into holo ‐Tf to obtain MnO2@Tf ‐ppIX nanoparticles (TMP). Because of the functional inheritance of holo‐Tf during fabrication, TMP can effectively traverse the BBB for highly specific magnetic resonance (MR) imaging of orthotopic glioblastoma. Clear suppression of tumor growth in a C6 tumor xenograft model is achieved via son odynamic therapy. Importantly, the experiments also indicate that the TMP nanoplatform has satisfactory biocompatibility and biosafety, ...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research