Doxorubicin ‐loaded polyphosphate glass microspheres for transarterial chemoembolization

We report here on doxorubicin (DOX)‐loaded polyphosphate glass microspheres (PGM) as a no vel resorbable, radiopaque, preloaded DEB‐TACE platform. Coacervate composed of polyphosphate chains complexed with Ba2+, Ca2+, and Cu2+ can be loaded with DOX prior to PGM synthesis, with PGM production achieved using a water ‐in‐oil emulsion technique at room temperature yielding highly spherical particles in clinically relevant size fractions. In vitro, DOX release was found to be linear, pH dependent, and in accordance with Type II non‐Fickian transport. PGM degradation was characterized by an initial burst rele ase of degradation products over 7 days, followed by a plateau in mass loss at approximately 75% over a period of several weeks. in vitro studies indicate that PGM degradation products, namely Cu2+, are cytotoxic and may interact with eluted DOX to impair its pharmacological activity. With additional compositional considerations, this approach may prove promising for DEB ‐TACE applications.
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - Category: Materials Science Authors: Tags: ORIGINAL RESEARCH REPORT Source Type: research