LncRNA XIST modulates HIF ‐1A/AXL signaling pathway by inhibiting miR‐93‐5p in colorectal cancer

ConclusionIn summary, the above results indicate thatXIST promotes colorectal cancer tumorigenesis by regulating miR ‐93‐5p/HIF ‐1A/AXL signaling pathway, which will supply a novel perspective to diagnose and treat colorectal cancer disease.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Findings from a large Swedish cohort show that any subtype of polyps will increase the risk for colorectal cancer, but only certain types raise the risk for cancer-related mortality.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Conditions:   Clinical Stage IV Gastric Cancer AJCC v8;   Clinical Stage IVA Gastric Cancer AJCC v8;   Clinical Stage IVB Gastric Cancer AJCC v8;   Malignant Uterine Neoplasm;   Metastatic Colorectal Carcinoma;   Metastatic Gastric Carcinoma;   Metastatic Malignant Neoplasm in  the Peritoneum;   Metastatic Ovarian Carcinoma;   Pathologic Stage IV Gastric Cancer AJCC v8;   Peritoneal Carc...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
While a group of stem cells within the intestine has been the main culprit for the growth of cancer, nearby fibroplats may harbor the real molecular villains.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news
Conclusion: This study has shown that simplification of ISH protocols by the use of COPs provides equivalent results to the use of LNA methods and it can be used to precisely identify cells in which miRNAs are expressed. PMID: 32223721 [PubMed - as supplied by publisher]
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research
A study finds similarities between cells that heal wounds and those that lead deadly cancerous invasions.
Source: The Scientist - Category: Science Tags: Notebook Magazine Issue Source Type: news
We report the genome-wide effects of KAP1 loss on the transcriptome, the chromatin state, and on recruitment of various components of the transcription machinery in the colon colorectal cancer cell line HCT116.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Other Homo sapiens Source Type: research
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00045
Source: Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
Contributors : Hiromu Suzuki ; Akira YorozuSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe identified adipocyte enhancer binding protein 1 (AEBP1) as a novel tumor endothelial marker in colorectal cancer (CRC). To identify target genes of AEBP1 in endothelial cells, we knocked down AEBP1 in human umbilical vein endothelial cells (HUVECs). We found that genes associated with angiogenesis including aquaporin 1 (AQP1) and periostin (POSTN) are downregulated by AEBP1 knockdown in HUVECs, suggesting that AEBP1 may promote tumor angiogenesis through regulating these genes.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
AbstractAlthough the application of laparoscopic rectal surgery has been widely accepted by accumulated evidence, it remains technically difficult in some cases of obesity, narrow male pelvis, bulky tumors, or involvement of adjacent organs. After robotic rectal surgery has been covered by the health insurance system in Japan since April 2018, we have employed robotic rectal surgery for an increasing number of cases by taking advantages of its 3D vision and wrist function. When a colorectal cancer involves the urinary bladder, the surgical treatment of choice is an anterior resection with en bloc (partial or total) bladder...
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research
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