Increased Estrogen Levels Altered MicroRNA Expression in Prostate and Plasma of Rats Dosed with Sex Hormones
ConclusionChronic inflammation in the dorsolateral prostate of rats dosed with EB, T and E resulted in deregulated expression in a set of microRNAs whose target genes were related to tumor growth or abnormal proliferation. Our findings suggest the identified microRNAs and their target genes the potential use as biomarkers to predict prostate cancer development. Validation using human samples is warranted.
Source: Andrology - Category: Urology & Nephrology Authors: Noriko Nakamura,
Kelly Davis,
Jian Yan,
Daniel T. Sloper,
Tao Chen Tags: ORIGINAL ARTICLE Source Type: research
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