Involvement of Tumor Necrosis Factor Receptor Type II in FoxP3 Stability and as a Marker of Treg Cells Specifically Expanded by Anti –Tumor Necrosis Factor Treatments in Rheumatoid Arthritis

ConclusionTNFRII expression identifies a subset of Treg cells that are characterized by stable expression ofFoxp3 via gene hypomethylation, and adoptive transfer of TNFRII ‐expressing Treg cells ameliorates inflammation in experimental models. Expansion and activation of TNFRII+ Treg cells may be one of the mechanisms by which anti‐TNF agents control inflammation in RA, but not in SpA.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research