Involvement of Tumor Necrosis Factor Receptor Type II in FoxP3 Stability and as a Marker of Treg Cells Specifically Expanded by Anti –Tumor Necrosis Factor Treatments in Rheumatoid Arthritis
ConclusionTNFRII expression identifies a subset of Treg cells that are characterized by stable expression ofFoxp3 via gene hypomethylation, and adoptive transfer of TNFRII ‐expressing Treg cells ameliorates inflammation in experimental models. Expansion and activation of TNFRII+ Treg cells may be one of the mechanisms by which anti‐TNF agents control inflammation in RA, but not in SpA.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Fran çois Santinon,
Maxime Batignes,
Majda Lyna Mebrek,
Jerôme Biton,
Gaëlle Clavel,
Roxane Hervé,
Delphine Lemeiter,
Magali Breckler,
Florence Busato,
Jorg Tost,
Marianne Ziol,
Marie‐Christophe Boissier,
Patrice Decker,
Luca Semerano, Tags: Original Article Source Type: research