Effect of Parkin on methamphetamine ‐induced α‐synuclein degradation dysfunction in vitro and in vivo

ConclusionsBy establishing stable cell lines and animal models that overexpress Parkin, we confirmed Parkin as an important factor in METH ‐induced α‐syn degradation dysfunction in vitro and in vivo. Parkin may be a promising target for the treatment of METH‐induced neurotoxicity.

Source: Brain and Behavior - February 27, 2020 Category: Neurology Authors: Yunle Meng, Honghua Qiao, Jiuyang Ding, Yitong He, Haoling Fan, Chen Li, Pingming Qiu Tags: ORIGINAL RESEARCH Source Type: research