Optimizing Isotretinoin Treatment of Acne: Update on Current Recommendations for Monitoring, Dosing, Safety, Adverse Effects, Compliance, and Outcomes
AbstractAcne vulgaris is the most common skin disease treated by dermatologists. It can be severe and result in permanent scars. Isotretinoin is the most effective treatment for acne and has the potential for long-term clearance. Prescribing and monitoring protocols can vary widely among prescribers. Recent studies, reports, and consensus statements help shed light on optimizing the use of isotretinoin for acne. A recent literature review is summarized in this article to help the practitioner optimize isotretinoin use for acne. The article outlines the advantages and disadvantages of standard, high-dose, and low-dose isotretinoin regimens; discusses the current status of controversies surrounding isotretinoin (including depression/suicide, pregnancy, and inflammatory bowel disease); reviews monitoring recommendations and treatment for hypertriglyceridemia and elevated transaminase levels; and discusses common adverse effects seen with isotretinoin, along with their treatment and prevention.
Publication date: Available online 31 May 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Badmus O. Olufunto, Njan Anoka, Ologe M. Olufunmilayo, Olatunji A. Lawrence
Providers involved in the care of children, adolescents, and adults with mental health issues are rightly focused on stabilizing those individuals. However, they should not forget the families and communities; they, too, are grieving with the toll of t...
We compared the efficacy and safety of transcranial direct current stimulation (tDCS) vs. Sertraline in the treatment of Major Depressive Disorder (MDD) in South Korean participants. This was a multi-center, double blind, active controlled study with non-i...
Publication date: Available online 31 May 2020Source: Mental Health and Physical ActivityAuthor(s): J.E. King, H. Jebeile, S.P. Garnett, L.A. Baur, S.J. Paxton, M.L. Gow
CONCLUSIONS: INI seem safe and effective in the prevention of MTCT. Our findings support their use as intensification regimens in pregnant women with high risk of MTCT. PMID: 32473739 [PubMed - as supplied by publisher]
Publication date: Available online 1 June 2020Source: Pregnancy HypertensionAuthor(s): Wenbo Zhou, Guangtong She, Kaiyan Yang, Bin Zhang, Jingbing Liu, Bin Yu
Publication date: Available online 1 June 2020Source: Pregnancy HypertensionAuthor(s): Osasumwen Asemota, Lennox Bryson, Joshua Fogel
Publication date: Available online 31 May 2020Source: Pregnancy HypertensionAuthor(s): Joshua I. Rosenbloom, Dustin Stwalley, Kathryn J. Lindley, D. Michael Nelson, Margaret A. Olsen, Molly J. Stout
Publication date: Available online 31 May 2020Source: Obstetrics and Gynecology Clinics of North AmericaAuthor(s): Haywood L. Brown
Publication date: Available online 31 May 2020Source: Obstetrics and Gynecology Clinics of North AmericaAuthor(s): Haywood L. Brown, Graeme N. Smith