Effects of intrauterine insulin-like growth factor-1 therapy for fetal growth restriction on adult metabolism and body composition are sex-specific.

Effects of intrauterine insulin-like growth factor-1 therapy for fetal growth restriction on adult metabolism and body composition are sex-specific. Am J Physiol Endocrinol Metab. 2020 Feb 26;: Authors: Spiroski AM, Oliver MH, Jaquiery AL, Gunn TD, Harding JE, Bloomfield FH Abstract Fetal growth restriction (FGR) is associated with compromised growth and metabolic function throughout life. Intrauterine therapy of FGR with intra-amniotic insulin-like growth factor-1 (IGF1) enhances fetal growth and alters perinatal metabolism and growth in a sex-specific manner, but the adult effects are unknown. We investigated the effects of intra-amniotic IGF1 treatment of FGR on adult growth and body composition, adrenergic sensitivity, and glucose-insulin axis regulation. Placental embolisation-induced FGR was treated with 4 weekly doses of 360 µg intra-amniotic IGF1 (FGRI) or saline (FGRS). Offspring were raised to adulthood (18 months: FGRI, n=12 females, 12 males; FGRS, n=13 females, 10 males) alongside offspring from un-embolised and untreated sheep (CON; n=12 females, 21 males). FGRI females had increased relative lean mass compared with CON but not FGRS (p<0.05; 70.6±8.2% vs. 61.4±8.2% vs. 67.6±8.2%), decreased abdominal adipose compared with CON and FGRS (p<0.05; 43.7±1.2% vs. 49.3±0.9% vs. 48.5±1.0%), increased glucose utilisation compared with FGRS but not CON (p<0.05; 9.6±1.0 vs. 6.0±0.9 vs. 7.6±0.9 mg·kgP-1P·minP-1...
Source: Am J Physiol Endocri... - Category: Endocrinology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research