LncRNAs a new target for post-stroke recovery.

LncRNAs a new target for post-stroke recovery. Curr Pharm Des. 2020 Feb 25;: Authors: Zhao J, Jun Y, Liu X, Zhu R Abstract LncRNAs (long non-coding RNAs) are endogenous molecules and involved in complicated biological processes. Increasing evidence has shown that lncRNAs play a vital role in the post-stroke pathophysiology.Furthermore, several lncRNAs were reported to mediate ischemia cascade processes include apoptosis, excitotoxicity, oxidative stress, angiogensis, neuroinfla- mmation, microglial cell which can cause neuron injury and influence neuron recovery after ischemic stroke. In our study, we first summarize current development about lncRNAs and post-stroke, focus on the regulatory roles of lncRNAs on pathophysiology after stroke.We also reviewed genetic variation in lncRNA associated with functional outcome after ischemic stroke. Additionally, lncRNA-based therapeutics offer promising strategies to decrease brain damage and promote neurological recovery following ischemic stroke.We are believed that lncRNAs will become promising and frontier strategies for IS and can open up a new path for the treatment of IS in the future. PMID: 32096739 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research