Clozapine in bipolar disorder: A systematic review and meta-analysis

Publication date: Available online 27 February 2020Source: Journal of Psychiatric ResearchAuthor(s): Andre Delgado, Jorge Velosa, Junyu Zhang, Serdar Dursun, Flavio Kapczinski, Taiane de Azevedo Cardoso
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research

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AbstractPurpose of ReviewThis paper aims to provide a succinct and narrative review of key developments in the diagnostic criteria, neurobiology, and treatment of bipolar disorder (BD).Recent FindingsDepressive symptoms/episodes and cognitive dysfunction are critical mediators of human capital, quality of life, and wellness in persons with BD. Significant advances in tolerability and incremental advances in efficacy exist with antimanic agents. Bipolar depression treatment options remain suboptimal with relatively few being metabolically neutral. In silico modeling and advanced computational methods provide promise to furt...
Source: Current Behavioral Neuroscience Reports - Category: Neuroscience Source Type: research
Autism seldom occurs in its pure form. Often labeled as behavioral disorders or psychological reactions, comorbid psychiatric disorders are common. Bipolar disorder is one of the most common psychiatric disorders that occur in persons with autism across their life spans. It can be comorbid with and mistaken for several other conditions. Similarly, psychosis occurs in several psychiatric disorders. Schizophrenia is the prototype psychotic disorder that has a close but controversial relationship with autism. Assessment and treatment of bipolar disorder and psychosis should be based on their individual characteristics, family...
Source: Child and Adolescent Psychiatric Clinics of North America - Category: Psychiatry Authors: Source Type: research
Major depressive disorder and bipolar disorder are prevalent and debilitating psychiatric disorders that are difficult to distinguish, as their diagnosis is based on behavioural observations and subjective sym...
Source: BMC Psychiatry - Category: Psychiatry Authors: Tags: Research article Source Type: research
Formation of a single new centriole from a pre-existing centriole is strictly controlled to maintain correct centrosome number and spindle polarity in cells. However, the mechanisms that govern this process are incompletely understood. Here, using several human cell lines, immunofluorescence and structured illumination microscopy methods, and ubiquitination assays, we show that the E3 ubiquitin ligase F-box and WD repeat domain–containing 7 (FBXW7), a subunit of the SCF ubiquitin ligase, down-regulates spindle assembly 6 homolog (HsSAS-6), a key protein required for procentriole cartwheel assembly, and thereby regula...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Accelerated Communications Source Type: research
Conditions:   Radiofrequency Ablation;   Carcinoma, Hepatocellular Intervention:   Procedure: RFA using combined bipolar and monopolar energy deliver Sponsor:   Seoul National University Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Polyps Uterus Intervention:   Procedure: Polypectomy without anesthesia or analgo-sedation Sponsor:   Hopital Foch Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Prostate Obstruction;   Prostatic Hyperplasia;   Prostatic Hypertrophy, Benign Interventions:   Procedure: Bipolar Vapo-Enucleation of the prostate;   Procedure: Bipolar Needlescopic Enucleation of the prostate Sponsor:   Benha University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Radiofrequency Ablation;   Carcinoma, Hepatocellular Intervention:   Procedure: RFA using combined bipolar and monopolar energy deliver Sponsor:   Seoul National University Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Polyps Uterus Intervention:   Procedure: Polypectomy without anesthesia or analgo-sedation Sponsor:   Hopital Foch Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Prostate Obstruction;   Prostatic Hyperplasia;   Prostatic Hypertrophy, Benign Interventions:   Procedure: Bipolar Vapo-Enucleation of the prostate;   Procedure: Bipolar Needlescopic Enucleation of the prostate Sponsor:   Benha University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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