HLA-G and humanized mouse models as a novel therapeutic approach in transplantation.

HLA-G and humanized mouse models as a novel therapeutic approach in transplantation.
Hum Immunol. 2020 Feb 21;:
Authors: Ajith A, Portik-Dobos V, Horuzsko DD, Kapoor R, Mulloy LL, Horuzsko A
Abstract
HLA-G is a nonclassical MHC-Class I molecule whose expression, along the feto-maternal barrier contributes towards tolerance of the semiallogeneic fetus during pregnancy. In light of its inhibitory properties, recent research has established HLA-G involvement in mechanisms responsible for directing allogeneic immune responses towards tolerance during allogeneic situations such as organ transplantation. Here, we critically review the data supporting the tolerogenic role of HLA-G in organ transplantation, the various factors influencing its expression, and the introduction of novel humanized mouse models that are one of the best approaches to assess the utility of HLA-G as a therapeutic tool in organ transplantation.
PMID: 32093884 [PubMed - as supplied by publisher]

Source: Human Immunology - February 20, 2020 Category: Allergy & Immunology Authors: Ajith A, Portik-Dobos V, Horuzsko DD, Kapoor R, Mulloy LL, Horuzsko A Tags: Hum Immunol Source Type: research