Combinatorial Synthesis of Benzimidazole-azo-phenol Derivatives as Antifungal Agents.

Combinatorial Synthesis of Benzimidazole-azo-phenol Derivatives as Antifungal Agents.
Comb Chem High Throughput Screen. 2013 Oct 20;
Authors: Ke Y, Zhi X, Yu X, Ding G, Yang C, Xu H
Abstract
A chemically diverse library of benzimidazole-azo-phenol derivatives was efficiently prepared and screened for their antifungal activities against five phytopathogenic fungi. Some compounds exhibited the potent antifungal activities. As compared with a commercially available agricultural fungicide, hymexazol, especially compound V-5 showed the most promising broad-spectrum antifungal activities against five phytopathogenic fungi. The EC50 values of V-5 against F. graminearum, A. solani, V. mali, B. cinerea, and C. lunata were 0.09, 0.08, 0.06, 0.07, and 0.11 μmol/mL, respectively.
PMID: 24152176 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - October 20, 2013 Category: Chemistry Authors: Ke Y, Zhi X, Yu X, Ding G, Yang C, Xu H Tags: Comb Chem High Throughput Screen Source Type: research