Synthesis of 2-Amino-4H-Chromen-4-yl Phosphonats via C-P Bond Formation Catalyzed by Nano-Rods ZnO Under Solvent-Free Condition.

Synthesis of 2-Amino-4H-Chromen-4-yl Phosphonats via C-P Bond Formation Catalyzed by Nano-Rods ZnO Under Solvent-Free Condition.
Comb Chem High Throughput Screen. 2013 Oct 20;
Authors: Hosseini-Sarvari M, Roosta A
Abstract
One-pot, three-component reactions of structurally diverse salicylaldehydes with malononitrile (or ethylcyanoacetate) and diethyl (or dimethyl) phosphate are carried out in the presence of nano-rods ZnO as an efficient catalyst for the synthesis of biologically interesting 2-amino-4H-chromen-4-yl phosphonate derivatives. The value of this method lies in its mild and environmentally benign reaction, simple procedure, good yields, and ease of handling.
PMID: 24152177 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - October 20, 2013 Category: Chemistry Authors: Hosseini-Sarvari M, Roosta A Tags: Comb Chem High Throughput Screen Source Type: research