Circulating and tissue specific transcription of angiopoietin-like protein 4 in human Type 2 diabetes
Obesity is associated with adipose tissue (AT) dysfunction marked by cellular hypertrophy, inflammation, hypoxia and fibrosis. Angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase which regulates triglyceride storage. Recently, inhibition of ANGPTL4 has been suggested as potential treatment for type 2 diabetes. Here we evaluate ANGPTL4 ’s role in diabetes and examine ANGPTL4 in relation to markers of AT dysfunction and fatty liver disease.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Laura J. McCulloch, Laura R. Bramwell, Bridget Knight, Katarina Kos Source Type: research