Melatonin suppression by melanopsin-weighted light in patients with bipolar I disorder compared to healthy controls

Conclusion: Despite using a large cohort and highly controlled laboratory conditions, we found no differences in melatonin suppression between euthymic patients with bipolar I disorder and healthy controls. These findings do not support the notion that supersensitivity is a valid endophenotype in bipolar I disorder. PMID: 32096617 [PubMed - in process]
Source: Journal of Psychiatry and Neuroscience - Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

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CONCLUSION: This study showed that CE on the visual sustained attention task seems to influence suicidal ideation as a result of interaction with depressive symptoms. PMID: 32252509 [PubMed - as supplied by publisher]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
Conclusions: We demonstrated histological evidence of persistent ectopic synapses, prolonged cellular apoptosis, and gliosis in the OIR retina that corresponded with long-term in vivo evidence of capillary attrition, inner retinal thinning, and dysfunction despite full peripheral revascularization. Further studies on the mechanisms underlying these persistent phenotypes could enhance our understanding of ROP pathogenesis and lead to new therapeutic targets to preserve visual function in premature infants. PMID: 32256029 [PubMed - as supplied by publisher]
Source: Molecular Vision - Category: Molecular Biology Tags: Mol Vis Source Type: research
Publication date: Available online 6 April 2020Source: Brain, Behavior, and ImmunityAuthor(s): C.E. Millett, J. Harder, J.J. Locascio, M. Shanahan, G. Santone, R. Fichorova, A. Corrigan, C. Baecher-Allan, K.E. Burdick
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Purpose of review To provide a framework for approaching ventricular arrhythmias in the setting of cardiomyopathy, outline the latest evidence-based recommendations for catheter ablation and device therapy, and discuss novel treatment strategies. Recent findings Risk stratification of ventricular arrhythmias in systolic heart failure has evolved, with an increasing role for cardiac magnetic resonance imaging to identify underlying substrate and scar burden. Medical therapy for heart failure has greatly improved, and the role of primary prevention defibrillators in nonischemic cardiomyopathy has become more ambiguous. ...
Source: Current Opinion in Cardiology - Category: Cardiology Tags: CARDIAC FAILURE: Edited by Rebecca Cogswell and Gene Kim Source Type: research
Source: Neuropsychiatric Disease and Treatment - Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
In conclusion, lithium confers protection to the skeleton but its clinical utility awaits further validation from human clinical trials.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
  Day 1,364 of the COVID-19 quarantine (well, at least it feels like it). How are you holding up? If you’re like most people, you’re not having much fun. But if you already struggle with anxiety, depression or another mental health issue, these days of isolation and uncertainty can feel like absolute torture. In today’s Not Crazy episode, Gabe laments the loss of his routine — those regular activities he clung to religiously to keep his mental health in check.  Now what is he supposed to do? Tune in for a special quarantine episode. Together, we will grieve our old routines and discuss...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic General Health-related Mental Health and Wellness Not Crazy Podcast Self-Help Source Type: blogs
Post-mortem brain studies suggest that miRNAs may be involved in suicide, but their role as peripheral biomarkers or targets of preventive pharmacological treatments in suicide has yet to be elucidated. We used nCounter miRNA Expression assay to measure mi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Integration of active electronics into photonic systems is necessary for large-scale photonic integration. While heterogeneous integration ...
Source: Optics Express - Category: Physics Authors: Source Type: research
AbstractPurpose of ReviewThis paper aims to provide a succinct and narrative review of key developments in the diagnostic criteria, neurobiology, and treatment of bipolar disorder (BD).Recent FindingsDepressive symptoms/episodes and cognitive dysfunction are critical mediators of human capital, quality of life, and wellness in persons with BD. Significant advances in tolerability and incremental advances in efficacy exist with antimanic agents. Bipolar depression treatment options remain suboptimal with relatively few being metabolically neutral. In silico modeling and advanced computational methods provide promise to furt...
Source: Current Behavioral Neuroscience Reports - Category: Neuroscience Source Type: research
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