Implementation of the Evidence Integration Triangle for the Management of Behavioral Psychological Symptoms of Dementia (EIT-4-BPSD) Intervention in a Nursing Home Setting.

Behavioral Psychological Symptoms of Dementia (BPSD) are described as symptoms of apathy, agitation, inappropriate vocalization, aggression, wandering, and resistiveness to care. Not managing BPSD appropriately can cause an increase in frustration, stress, and burnout amongst staff members, and negatively impacts the health and quality of life for residents with dementia. Psychotropic medications are often administered to residents with BPSD in long-term care facilities and can lead to adverse effects such as an increase in falls, mortality, cardiovascular events, and hospitalizations.
Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Source Type: research

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Purpose of review People with Down syndrome represent the world's largest population with a genetic risk for Alzheimer's disease. This review will provide a short summary of what is known and will include recent findings from the field. Recent findings There has been an increasing focus on biomarker research in this population, with a number of studies presenting findings on promising new markers – Neurofilament Light (NfL) appears to be one such promising marker that has emerged. Imaging studies have increased our knowledge on the progression of Alzheimer's disease in this population. Summary The inclusion o...
Source: Current Opinion in Psychiatry - Category: Psychiatry Tags: GERIATRIC PSYCHIATRY Source Type: research
Purpose of review Antiamyloid therapy of Alzheimer's disease tackles the overproduction and clearance of the amyloid-beta peptide (Aβ). Immunotherapeutic compounds were tested in large-scale trials. We revisit the recent literature focusing on randomized-controlled trials (RCT) using monoclonal anti-Aβ antibodies. Recent findings Forty-three articles on anti-Aβ passive immunotherapy for Alzheimer's disease were published between January 2016 and October 2019 regarding 17 RCTs: 13 phase III trials using the monoclonal antibodies bapineuzumab, solanezumab, gantenerumab, crenezumab, and aducanumab; three p...
Source: Current Opinion in Psychiatry - Category: Psychiatry Tags: GERIATRIC PSYCHIATRY Source Type: research
Conditions:   Obstructive Sleep Apnea;   Alzheimer Disease;   Vascular Dementia;   Mild Cognitive Impairment;   Parkinsons Disease With Dementia;   Dementia With Lewy Bodies;   Mixed Dementia Interventions:   Device: In-laboratory polysomnography;   Device: Home Sleep Apnea Test Sponsors:   Sunnybrook Health Sciences Centre;   St. Michael's Hospital, Toronto Recruiting
Source: - Category: Research Source Type: clinical trials
Conditions:   Cognitive Decline;   Dementia, Vascular;   Alzheimer Disease;   Dementia;   Stroke Interventions:   Other: Behavioral Dietary intervention ( MIND Diet);   Other: Behavioral Usual Care Diet Intervention Sponsors:   Rush University Medical Center;   University of Chicago;   Advocate Hospital System;   National Institute on Aging (NIA) Not yet recruiting
Source: - Category: Research Source Type: clinical trials
CONCLUSION: Older adults with non-communicable diseases have high prevalence of cognitive impairment. Physicians should make the patients and their family members aware about the association of non-communicable diseases with cognitive impairments and should encourage these persons to use remedial measures to reduce the risk of future development of dementia. PMID: 32248085 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Conclusion: It is worth educating the public about dementia and developing strategies consistent with their preferences for types of mass media.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
AbstractCognition-oriented treatments – commonly categorized as cognitive training, cognitive rehabilitation and cognitive stimulation – are promising approaches for the prevention of cognitive and functional decline in older adults. We conducted a systematic overview of meta-analyses investigating the efficacy of cognition-oriented treatments on cognitive and non-cognitive outcomes in older adults with or without cognitive impairment. Review quality was assessed by A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR). We identified 51 eligible reviews, 46 of which were included in the quantitative synthe...
Source: Neuropsychology Review - Category: Neuroscience Source Type: research
American Journal of Psychiatry, Ahead of Print.
Source: American Journal of Psychiatry - Category: Psychiatry Authors: Source Type: research
Progranulin (PGRN) is a glycoprotein that is widely expressed among organs, including the central nervous system. PGRN insufficiency is involved in various neurodegenerative disorders such as frontotemporal dementia, Alzheimer’s disease, and neuronal ceroid lipofuscinosis. One of the major causes of neuronal damage is hyperactivation of the cerebrum triggered by upregulation of excitatory systems. In the present study, we examined the possible involvement of PGRN in modulating excitability of the cerebrum using wild type and PGRN-deficient mice. First, we treated wild type and PGRN-deficient mice with seizure-inducib...
Source: NeuroReport - Category: Neurology Tags: Degeneration and Repair Source Type: research
Conditions:   Dementia;   Alzheimer Disease;   Caregiver Burnout;   Family Members Intervention:   Behavioral: STELLA (Support via TEchnology: Living and Learning with Advancing Alzheimer's disease and related dementias) Sponsors:   Oregon Health and Science University;   National Institute on Aging (NIA) Recruiting
Source: - Category: Research Source Type: clinical trials
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