Cardiac catheterization procedures in children with congenital heart disease: increased chromosomal aberrations in peripheral lymphocytes

Publication date: Available online 25 February 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Yu Gao, Ping Wang, Yinping Su, Zhaonan Wang, Lin Han, Jie Li, Yinghua Fu, Fengling Zhao, Quanfu Sun, Yumin Lyu
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research

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AbstractPulmonary artery aneurysm (PAA) is a common finding in patients with long-term pulmonary arterial hypertension (PAH). The influence of PAH severity in the development of PAA remains unclear. We sought to determine whether PAA development is related to PAH severity and whether treatment optimization based on risk profile estimation is effective to stop pulmonary artery (PA) enlargement. This is a retrospective study of 125 PAH patients who underwent an imaging test (computed tomography or magnetic resonance) combined with a right heart catheterization within a six-month period. A multivariate analysis was performed ...
Source: Heart and Vessels - Category: Cardiology Source Type: research
DiscussionSevoflurane is the most frequently used  anesthetic in young children, but has been indicated as an independent risk factor in the development of emergence delirium. Xenon and dexmedetomidine have both been associated with a reduction in the incidence of emergence delirium. Combining xenon and dexmedetomidine has never been described as a balanced-anesthesia technique in children. Our pilot study will therefore deliver important data required for future prospective clinical trials.Trial registrationEudraCT, 2018 –002258-56. Registered on 20 August 2018.https://www.clinicaltrialsregister.eu.
Source: Trials - Category: Research Source Type: clinical trials
el NF Abstract BACKGROUND: In animal models of pulmonary arterial hypertension (PAH), angiotensin converting enzyme type 2 (ACE2) and Angiotensin 1-7 [Ang-(1-7)] have been shown to have vasodilatory, anti-proliferative, anti-fibrotic and anti-hypertrophic properties. However, the status and role of the ACE2-Ang-(1-7) axis in human PAH is incompletely understood. METHODS: We studied 85 patients with a diagnosis of PAH of distinct etiologies. Fifty-five healthy blood donors paired for age and sex served as controls. Blood samples were obtained from the pulmonary artery in patients with PAH during right heart ca...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Eur Respir J Source Type: research
Objectives: We investigated whether concentrations of circulating microRNAs differ across the hypertensive right ventricle and pulmonary circulation, and correlate with hemodynamic/echocardiographic variables in patients with pulmonary arterial hypertension versus nonpulmonary arterial hypertension controls. Design: Prospective blood collection during cardiac catheterization from the superior vena cava, pulmonary artery, and ascending aorta in 12 children with pulmonary arterial hypertension and nine matched nonpulmonary arterial hypertension controls, followed by an unbiased quantitative polymerase chain reaction arr...
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Feature Cardiac Intensive Care Source Type: research
Children on ventricular assist device (VAD) support often present unique challenges, such as small size, univentricular or biventricular congenital heart disease (1V- or 2V-CHD), and need for biventricular (BiVAD) support. While cardiac catheterization (cath) can provide valuable information in the management of pediatric patients on VAD support, it is an invasive procedure with inherent risks. We sought to evaluate the safety of cath in this population.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1185) Source Type: research
Today ’s standard of care, in the congenital heart disease (CHD) population, involves performing cardiac catheterization under x-ray fluoroscopy and cardiac magnetic resonance (CMR) imaging separately. The uniq...
Source: Journal of Cardiovascular Magnetic Resonance - Category: Radiology Authors: Tags: Technical notes Source Type: research
ConclusionsThe SV ‐INHIBITION study aims to answer the question whether PDE5 inhibitors should be prescribed in patients with an SV. This trial has been built focusing on the three levels of research defined by the World Health Organization: disability (exercise tolerance), deficit (SV function), and handicap (qual ity of life).
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Study Design Source Type: research
The study of Dragu R et al. published recently in International Journal of Cardiology [1] aroused our great interest. In order to further understand the influence of different hemodynamic methods, we observed the evaluation of exercise capacity in combined post- and pre-capillary pulmonary hypertension (Cpc-PH) patients. Fifty patients with PH due to left heart disease (PH-LHD) who underwent right heart catheterization and cardiopulmonary exercise test (CPET) were divided into Cpc-PH according to PVR  > 3WU or DPG ≥ 7 mmHg or trans-pulmonary gradient (TPG) ≥ 12 mmHg, respectively.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Letter to the editor Source Type: research
Congenital coronary artery anomalies, both in isolation and associated with other forms of congenital heart disease, have been recognized as important lesions with significant potential morbidity and mortality, including sudden cardiac death in children and adolescents. Multimodality imaging techniques have demonstrated increasing utility in the characterization of most congenital coronary anomalies, both in children and adults, and may reduce the need for diagnostic catheterization in many cases.
Source: Journal of the American Society of Echocardiography - Category: Cardiology Authors: Tags: Guidelines and Standards Source Type: research
;o LR Abstract BACKGROUND: The role of cardiac catheterization in pediatrics has progressed significantly over the last two decades, evolving from a primary diagnostic tool to a primary treatment modality in children with congenital heart disease. Vascular complications, particularly arterial thrombosis, are among the most common unwanted post-cardiac catheterization events. In 1974, unfractionated heparin proved to be superior to placebo in decreasing the incidence of arterial thrombosis in pediatric patients. However, the optimal dose of unfractionated heparin to be utilized in this setting remains a matter of c...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
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