A novel variant near LSP1P3 is associated with knee osteoarthritis in the Chinese population

ConclusionsThe association of rs4867568 and rs143383 with KOA was successfully replicated in the Chinese Han population. Moreover, rs4867568 was found significantly associated with the severity of KOA. More studies are warranted to explore the functional role of rs4867568 in the development of KOA.Key Points• A novel variant near Lsp1p3 is associated with knee osteoarthritis.• Baseline characteristics of the subjects.• Comparison of the genotype and allele frequency of the Lsp1p3, GDF5, and FTO.• Association of the Lsp1p3, GDF5, and FTO with KOA severity.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research