A novel variant near LSP1P3 is associated with knee osteoarthritis in the Chinese population

ConclusionsThe association of rs4867568 and rs143383 with KOA was successfully replicated in the Chinese Han population. Moreover, rs4867568 was found significantly associated with the severity of KOA. More studies are warranted to explore the functional role of rs4867568 in the development of KOA.Key Points• A novel variant near Lsp1p3 is associated with knee osteoarthritis.• Baseline characteristics of the subjects.• Comparison of the genotype and allele frequency of the Lsp1p3, GDF5, and FTO.• Association of the Lsp1p3, GDF5, and FTO with KOA severity.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research

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Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Clinical Trial Source Type: research
Condition:   Hip Osteoarthritis Intervention:   Device: Surgery Sponsor:   Zimmer Biomet Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Osteoarthritis, Knee Interventions:   Biological: Autologous Mesenchymal Stem Cells Treatment (MSCs);   Drug: Hyaluronic acid (HA) Sponsor:   Chinese University of Hong Kong Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Pain Reduction;   Physical Function Improvement Interventions:   Drug: 25 mg/week oral methotrexate tablets;   Drug: 25mg/week oral placebo tablets Sponsor:   University of Alexandria Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Hip Osteoarthritis Intervention:   Device: Surgery Sponsor:   Zimmer Biomet Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Osteoarthritis, Knee Interventions:   Biological: Autologous Mesenchymal Stem Cells Treatment (MSCs);   Drug: Hyaluronic acid (HA) Sponsor:   Chinese University of Hong Kong Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Pain Reduction;   Physical Function Improvement Interventions:   Drug: 25 mg/week oral methotrexate tablets;   Drug: 25mg/week oral placebo tablets Sponsor:   University of Alexandria Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
(Tokyo University of Science) In Japan, an increase in the aging population has exacerbated the demand for regenerative medicine to address increasingly common diseases, such as knee osteoarthritis. In a new study, scientists from Tokyo University of Science, led by Prof Hidenori Otsuka, have developed a novel biocompatible hydrogel that acts as a structural scaffold for the growth of cartilage-producing cells, showcasing a promising new tool for tissue regeneration.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
This study compares psychological and somatosensory characteristics between those with persistent PFP and controls.Methods150 adults with PFP were compared to 61 controls. All participants completed a survey evaluating participant characteristics, PFP ‐related constructs and psychological factors: anxiety, depression, pain catastrophizing, kinesiophobia, pain self‐efficacy. Participants also attended a session of somatosensory testing, which included knee and elbow thermal and mechanical detection and pain thresholds, conditioned pain modulat ion (CPM), and temporal summation of pain (TSP). Differences were evaluated u...
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
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