Clinical Trial Evaluating Lumateperone Monotherapy in the Treatment of Bipolar Depression

Condition:   Bipolar Depression Interventions:   Drug: Lumateperone;   Drug: Placebos Sponsor:   Intra-Cellular Therapies, Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

Related Links:

In this study, we examined the prevalence of posttraumatic stress disorder (PTSD) in 3800 psychiatric outpatients with different principal diagnoses. For all disorders identified as a principal diagnosis, we compared patients' odds ratios of PTSD to all other patients in the sample. Approximately one-sixth of the sample (n = 663, 17.4%) was diagnosed with PTSD, including 417 patients with current PTSD and 246 with PTSD in partial remission. Patients with principal bipolar disorder and major depressive disorder (MDD) demonstrated higher rates of PTSD compared with those without principal bipolar and MDD. For most psychiatri...
Source: The Journal of Nervous and Mental Disease - Category: Psychiatry Tags: Original Articles Source Type: research
Authors: Tortella G, Sampaio-Junior B, Moreno ML, Moffa AH, da Silva AF, Lafer B, Lotufo PA, Gattaz W, Borrione L, Machado-Vieira R, Goerigk S, Benseñor IM, Brunoni AR Abstract Bipolar depression is associated with marked cognitive deficits. Pharmacological treatments for this condition are limited and may aggravate depressive and cognitive symptoms. Therefore, therapeutic interventions that preserve adequate cognitive functioning are necessary. Our previous results demonstrated significant clinical efficacy of transcranial direct current stimulation (tDCS) in the Bipolar Depression Electrical Treatment Tria...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
The objective of this study was to examine the lifetime prevalence of OCD, the strength of the association of OCD with comorbid BDS and the role of comorbidity of OCD with BDS in the impairment of health-related quality of life (HRQoL) in an Italian community survey.Methods: The study is a community survey. The sample (N = 2,267; women: 55.3%) was randomly selected after stratification by sex and four age groups from the municipal records of the adult population of one urban, one suburban, and at least one rural area in six Italian regions. Physicians using a semi-structured interview (Advanced Tools and Neuropsychiatric A...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
The word “bipolar” has become colloquially associated with anything that changes rapidly or is unpredictable: the weather, technology, sports teams, politics, or even a teenager’s attitude. But for roughly 46 million people worldwide, being “bipolar” is far more serious than typical unpredictability, mood swings, or temperamental behavior. And, when bipolar disorder is complicated by substance use disorder (SUD), the situation can become incredibly dangerous for the individual and those around them. Recognizing the symptoms of bipolar and the complicating factors of substance use disorder is c...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Addiction Alcoholism Bipolar Recovery Substance Abuse Addiction Recovery Bipolar Disorder Detox Dual Diagnosis World Bipolar Day Source Type: blogs
  Cannabis, weed, marijuana, pot. It goes by several names, but we all know what it smells like. As weed becomes more mainstream, we on the Not Crazy podcast want to know: Is marijuana really an effective treatment for anxiety? Is it just a coping mechanism? Or a vice? In today’s podcast, Gabe and Jackie look at the research and weigh out the evidence. They also interview Eileen Davidson, a rheumatoid arthritis patient who regularly uses marijuana as a medicine to see what she has to say. What’s your take? Tune in for an open-minded discussion about weed. (Transcript Available Below) SUBSCRIBE &REV...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic General Medications Not Crazy Podcast Source Type: blogs
Conclusions: While this is a very small sample, asenapine appears to have a beneficial effect on both depression and anxiety in depressed bipolar I patients compared to treatment with placebo. Due to the large fraction of subjects with the short form, the hypothesis that the SF-5HTTR might increase asenapine response could not be adequately tested. PMID: 32214517 [PubMed - in process]
Source: Psychopharmacology Bulletin - Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research
This double-blind placebo-controlled, fixed/flexible-dose phase 2 trial assessed the efficacy, safety, and tolerability of cariprazine vs. placebo for depressive episodes associated with bipolar I or II disorder. Primary endpoint was change in Montgomery–Åsberg Depression Rating Scale (MADRS) total scores (baseline to week 8), and secondary endpoint was mean Clinical Global Impressions-Improvement score (week 8). Patients were randomized (N = 233) 1:1:1 to placebo, ‘low-dose’ 0.25–0.5 mg/day or ‘high-dose’ 1.5–3.0 mg/day cariprazine. Adverse events...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Original Articles Source Type: research
AbstractBipolar depression is associated with marked cognitive deficits. Pharmacological treatments for this condition are limited and may aggravate depressive and cognitive symptoms. Therefore, therapeutic interventions that preserve adequate cognitive functioning are necessary. Our previous results demonstrated significant clinical efficacy of transcranial direct current stimulation (tDCS) in the Bipolar Depression Electrical Treatment Trial (BETTER). Here, cognitive outcomes of this study are reported. We randomized 59 patients with bipolar disorder I or II in an acute depressive episode to receive active (12 2  mA...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
CONCLUSION: There is sufficient evidence to propose light therapy in a bipolar depressive episode with or without seasonal features. PMID: 32207132 [PubMed - in process]
Source: Tijdschrift voor Psychiatrie - Category: Psychiatry Authors: Tags: Tijdschr Psychiatr Source Type: research
AbstractPurpose of ReviewThe nosology and management of antidepressant-associated hypomania (AAH) in the treatment of unipolar depression requires clarification. We sought to review recent studies examining AAH, focusing on risk factors, differing explanatory models, and management strategies.Recent FindingsAAH occurs more frequently in those of female gender, younger age, and with a bipolar disorder (BP) family history. Depressive features (e.g., suicidal ideation, psychotic symptoms) in those with AAH were similar to those with established BPs. Explanatory models for AAH describe it as (i) a transient iatrogenic event, (...
Source: Current Psychiatry Reports - Category: Psychiatry Source Type: research
More News: Bipolar | Clinical Trials | Depression | Mania | Research