Persistent Mitral Regurgitation After TAVR Bodes Ill in Some Persistent Mitral Regurgitation After TAVR Bodes Ill in Some

Patients with low-flow, low-gradient aortic stenosis (LFLG-AS) who don't show improvement in mitral regurgitation following transcatheter aortic-valve replacement (TAVR) face an increased risk of mortality, according to a substudy of a multicenter registry.Reuters Health Information
Source: Medscape Radiology Headlines - Category: Radiology Tags: Cardiology News Source Type: news

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The bioresource (>265 patients with>27,600 biospecimens until December 2019; recruitment ongoing)  on severe aortic stenosis is of vital importance to improve the still incomplete understanding of its etiology as well as its transition to heart failure. The bioresource contains various biospecimens, standardised clinical and imaging data sets including transthoracic echocardiography, compute d tomography and magnetic resonance imaging of the heart. Biospecimen sampling follows the SOP-driven collection scheme of the German Center for Cardiovascular Research (DZHK) for venous blood and urine [...
Source: Open Journal of Bioresources - Category: Biotechnology Source Type: research
CONCLUSIONS: BAV is an effective treatment modality for AS in children of all age groups, which postpones the need for surgical treatment. Late follow-up reveals progression of AR. A greater reduction in PGmax is a risk factor for at least moderate AR directly post BAV, which results in the progression of AR at late follow-up and the need for performing heart surgery sooner. PMID: 32207700 [PubMed - as supplied by publisher]
Source: Kardiologia Polska - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research
Abstract BACKGROUND: Aortic valve replacement in patients with a small aortic root is a matter of concern in terms of prosthesis-patient mismatch. We evaluated the survival and hemodynamic performance after implantation of a small rapid-deployment aortic valve (Edwards Intuity Valve System sizes 19 and 21 mm). METHODS: Between May 2010 and November 2018, 659 consecutive patients with severe aortic stenosis who received a rapid-deployment valve were included in a prospective and ongoing database. A small aortic bioprosthesis (sizes 19 and 21 mm) was implanted in 217 patients (32.9%), mean age 74.9±7.9 y...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
dríguez JA, López-Andrés N Abstract OBJECTIVE: Aortic valve (AV) calcification plays an important role in the progression of aortic stenosis (AS). MMP-10 (matrix metalloproteinase-10 or stromelysin-2) is involved in vascular calcification in atherosclerosis. We hypothesize that MMP-10 may play a pathophysiological role in calcific AS. Approach and Results: Blood samples (n=112 AS and n=349 controls) and AVs (n=88) from patients undergoing valve replacement were analyzed. Circulating MMP-10 was higher in patients with AS compared with controls (P
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research
In previous studies of septal heart muscle from HCM patients with hypertrophic obstructive cardiomyopathy (HOCM, LVOT gradient 50–120 mmHg) we found that the level of phosphorylation of troponin I (TnI) and myosin binding protein C (MyBP-C) was extremely low yet samples from hearts with HCM or DCM mutations that did not have pressure overload were similar to donor heart controls. We therefore investigated heart muscle samples taken from patients undergoing valve replacement for aortic stenosis, since they have pressure overload that is unrelated to inherited cardiomyopathy. Thirteen muscle samples from septum and fro...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
ConclusionThis case demonstrates that QAV stenosis can be treated using TAVI with good clinical outcomes.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research
We present a case of an octogenarian who died in hospital less than a day after an initially satisfactory TAVI. Cardiologists suspected a combination of cardiogenic and hemorrhagic shock as the cause of death. Autopsy showed rupture of an extensive aortic dissection, which had developed within 24  h after the procedure. The cause of death was eventually defined as internal bleeding due to a rapid two-stage vascular process. The manner of death was considered accidental because an iatrogenic vessel injury beyond the aortic arch was causative for the death. This unusual case highlights the po tential for rare, but fatal...
Source: Forensic Science, Medicine, and Pathology - Category: Forensic Medicine Source Type: research
Authors: Alperi Garcia A, Muntané-Carol G, Junquera L, Del Val D, Faroux L, Philippon F, Rodés-Cabau J Abstract Introduction: Transcatheter aortic valve replacement (TAVR) has been demonstrated to be a good alternative to surgery for treating severe aortic stenosis (AS) across the whole range of surgical risk patients. Whereas most periprocedural TAVR complications have significantly decreased over time, conduction disturbances remain high. Approaches to decrease this shortcoming are under continuous investigation.Areas covered: Overview of the actual evidence regarding conduction disturbances in the ...
Source: Expert Review of Medical Devices - Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research
AbstractTwo randomized control trials demonstrated that transcatheter aortic valve implantation was associated with 1 –2 year clinical outcomes comparable or even superior to surgical aortic valve replacement (SAVR) in low surgical risk patients with severe aortic stenosis (AS). However, no previous study has reported the clinical outcomes after SAVR in Japanese patients with low surgical risk. From 3815 consecu tive patients enrolled in the CURRENT AS registry, we retrieved 220 patients who underwent SAVR in reference to the inclusion and exclusion criteria of the PARTNER 3 trial. Age and surgical risk score in...
Source: Cardiovascular Intervention and Therapeutics - Category: Cardiology Source Type: research
We aimed to analyze the association between flow patterns, gene expression and histological alterations of the proximal aorta in patients with aortic valve disease.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
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