Inhibition of Bladder Overactivity by Duloxetine in Combination with Foot Stimulation or WAY100635 Treatment in Cats.

Inhibition of Bladder Overactivity by Duloxetine in Combination with Foot Stimulation or WAY100635 Treatment in Cats. Am J Physiol Renal Physiol. 2013 Oct 23; Authors: Schwen Z, Matsuta Y, Shen B, Wang J, Roppolo JR, de Groat WC, Tai C Abstract The purpose of this study is to determine whether duloxetine (a serotonin-norepinephrine reuptake inhibitor) combined with transcutaneous foot stimulation or WAY100635 (a 5HT1A antagonist) can enhance inhibition of bladder overactivity in cats. Cystometrograms were performed on 8 cats under α-chloralose anesthesia by infusing saline and then 0.25% acetic acid (AA) to induce bladder overactivity. To inhibit bladder overactivity, foot stimulation (5 Hz) was applied via transcutaneous pad electrodes to the right hind foot at 2 and 4 times the threshold (T) intensity for inducing a toe twitch. Duloxetine (0.003-3 mg/kg) was administered intravenously to determine the effect of combination treatment. After the 3 mg/kg dose of duloxetine, WAY100635 (0.5 mg/kg) was given intravenously. AA irritation significantly (P
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
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Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
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