The Myelodepletive Phenotype in Myelofibrosis: Clinical Relevance and Therapeutic Implication

Myelofibrosis (MF) is a BCR-ABL1 negative myeloproliferative neoplasm (MPN) that arises from hematopoietic stem/progenitor cells frequently harboring a somatic driver mutation in one of three genes: JAK2, CALR or MPL. Pathologic features of this hematologic malignancy include myeloproliferation, diffuse bone marrow fibrosis, and overactivation of the JAK-STAT pathway resulting in enhanced inflammatory cytokine release. Common clinical manifestations of MF include systemic symptoms, abnormal peripheral blood counts and splenomegaly, however, it has become increasingly appreciated that there is significant clinical heterogeneity among MF patients.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Review Article Source Type: research