Chaperone-Based Therapeutic Target Innovation: Heat Shock Protein 70 (HSP70) for Type 2 Diabetes Mellitus

Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research

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Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
nson Metabolic syndrome is a cluster of interrelated conditions that is associated with an increased risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Oxidative stress may impair normal physiological functions, leading to various illnesses. T2DM is considered to be associated with increased oxidative stress, inflammation, and dyslipidemia, which may play a significant role in the development of cardiovascular complications, cancer and vision loss through cataracts and retinopathy. While conventional therapies are a cornerstone for the management of the major risk factors of metabolic syndrome, i...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
PREVALENCE OF VITAMIN D DEFICIENCY IN URBAN SOUTH INDIANS WITH DIFFERENT GRADES OF GLUCOSE TOLERANCE. Br J Nutr. 2020 Mar 26;:1-24 Authors: Jayashri R, Venkatesan U, Shanthi Rani CS, Deepa M, Anjana RM, Mohan V, Pradeepa R Abstract The present study assessed the prevalence of vitamin D deficiency in an urban south Indian population in individuals with different grades of glucose tolerance.A total of 1,500 individuals [900 normal glucose tolerance(NGT), 300 prediabetes and 300 with type 2 diabetes mellitus(T2DM)] who were not on vitamin D supplementation were randomly selected from the Chennai Urban Ru...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Authors: Kitazawa T, Park CH, Hiratani K, Choi JS, Yokozawa T Abstract Metabolic syndrome is a cluster of risk factors for cardiovascular disease and type 2 diabetes mellitus. The risk factors include hypertension, dyslipidemia, hyperglycemia, and central obesity. Various diagnostic criteria have been proposed by different organizations over the past decade. The utilization of traditional Chinese medicine to treat metabolic syndrome has received increasing attention due to its wide availability. In this paper, we report the case of a 68-year-old patient with hypertension, hypercholesterolemia, borderline diabetes, ...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
L, Estruch R, Lapetra J, Pintó X, Tur JA, Garcia-Rios A, García Molina L, Gaforio JJ, Matía-Martín P, Daimiel L, Martín Sánchez V, Vidal J, Prieto L, Ros E, Goñi N, Babio N, Ortega-Azorin C, Castañer O, Konieczna J, Notario Barandiaran L, Vaquero-Luna J, Benavente-Marín JC, Zulet MA, Sanchez-Villegas A, Sacanella E, Gómez Huelgas R, Miró-Moriano L, Gimenez-Gracia M, Julibert A, Razquin C, Basora J, Portolés O, Goday A, Galmés-Panadés AM, López-García CM, Moreno-Rodriguez A, Toledo E, Díaz-López A, ...
Source: Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Obesity (Silver Spring) Source Type: research
This study was designed to investigate the association of rs7903146 (C/T) polymorphism of TCF7L-2 gene with non-alcoholic fatty liver disease (NAFLD) in Asian Indians.MethodsIn this case-control study 162 non-diabetic subjects with NAFLD and 173 body mass index (BMI)-matched controls without NAFLD were recruited. Abdominal ultrasound, clinical and biochemical investigations, fasting insulin levels and value of homeostasis model assessment of insulin resistance (HOMA-IR) was measured. Single nucleotide polymorphism rs7903146 (C/T) was genotyped by polymerase chain reaction–restriction fragment length polymorphisms.Res...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
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