Top-Down Projections Direct the Gradual Progression of Alzheimer-Related Tau Pathology Throughout the Neocortex.

Top-Down Projections Direct the Gradual Progression of Alzheimer-Related Tau Pathology Throughout the Neocortex. Adv Exp Med Biol. 2019;1184:291-303 Authors: Braak H, Del Tredici K Abstract In sporadic Alzheimer's disease (sAD), tau pathology gradually but relentlessly progresses from the transentorhinal region of the temporal lobe into both the allocortex and temporal high order association areas of the neocortex. From there, it ultimately reaches the primary sensory and motor fields of the neocortex. The brunt of the changes seen during neurofibrillary stages (NFT) I-VI is borne by top-down projection neurons that contribute to cortico-cortical connectivities between different neocortical fields. Very early changes develop in isolated pyramidal cells in layers III and V, and these cells are targets of top-down projections terminating in association areas of the first temporal gyrus or in peristriate regions of the occipital lobe. Neurofibrillary pathology in these regions is routinely associated with late NFT stages. Sequential changes occur in different cell compartments (dendritic, somatic, axonal) of these early-involved neurons. Tau pathology first develops in distal segments of basal dendrites, then in proximal dendrites, the soma, and, finally, in the axon of affected pyramidal neurons. This sequence of abnormal changes supports the concept that axons of cortico-cortical top-down neurons may carry and spread abnormal tau seeds in a focused manner ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research

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CONCLUSION: Compared with those among older people who did not exercise, measures of olfaction among older adults who exercised were better, and the type of physical exercise mattered. Therefore, if physical exercise intervention is suggested to prevent or delay olfactory deterioration in older adults, the type of physical exercise should be considered. PMID: 32249853 [PubMed - in process]
Source: Rhinology - Category: ENT & OMF Tags: Rhinology Source Type: research
Publication date: May 2020Source: Journal of Biomedical Informatics, Volume 105Author(s): Ning An, Huitong Ding, Jiaoyun Yang, Rhoda Au, Ting F.A. Ang
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research
Aging is a condition that may be characterized by a decline in physical, sensory, and mental capacities, while increased morbidity and multimorbidity may be associated with disability. A wide range of clinical conditions (e.g., frailty, mild cognitive impairment, metabolic syndrome) and age-related diseases (e.g., Alzheimer's and Parkinson's disease, cancer, sarcopenia, cardiovascular and respiratory diseases) affect older people. Virtual reality (VR) is a novel and promising tool for assessment and rehabilitation in older people. Usability is a crucial factor that must be considered when designing virtual systems for medi...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
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Source: Current Opinion in Psychiatry - Category: Psychiatry Tags: GERIATRIC PSYCHIATRY Source Type: research
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Source: Current Opinion in Psychiatry - Category: Psychiatry Tags: GERIATRIC PSYCHIATRY Source Type: research
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Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
The foods that contained the highest levels of dementia-fighting antioxidants. → Support PsyBlog for just $5 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia subscribers-only Source Type: blogs
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Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
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Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
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Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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