Efficacy and Safety of Lebrikizumab in Adults With Moderate to Severe Atopic Dermatitis

This phase 2b, placebo-controlled, randomized clinical trial evaluates the efficacy and safety of lebrikizumab, a novel, high-affinity, monoclonal antibody targeting interleukin (IL) –13 that selectively prevents formation of the IL-13Rα1/IL-4Rα heterodimer receptor signaling complex, in adults with moderate to severe atopic dermatitis.
Source: JAMA Dermatology - Category: Dermatology Source Type: research

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Contributors : Xuehua Piao ; Ryosuke Miura ; Ryodai Shindo ; Hiroyasu NakanoSeries Type : Expression profiling by arrayOrganism : Mus musculusCellular FLICE-inhibitory protein (cFLIP) prevents the development of dermatitis by blocking TNF α-dependent apoptosis of keratinocytes. However, it is unclear whether TNFα-independent signal might also contribute to the development of dermatitis in epidermis-specific Cflar-deficient (Cflar) mice. Here we show that Cflar;Tnfrsf1a-/- mice were born at the expected Mende lian ratio, but developed severe dermatitis and succumbed soon after birth. Whil...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
We present a case of a 51 ‐year‐old Japanese woman diagnosed with eosinophilic granulomatous polyangiitis (EGPA), a rare vasculitis that can occur in patients with eosinophilia and history of asthma, allergic rhinitis, and sinusitis, with immunoglobulin (Ig) G4 hypergammaglobulinaemia and salivary gland swelling. AbstractA 51 ‐year‐old woman was admitted to our hospital for cough, fever, purpura in the legs, and salivary gland swelling. Six years ago, she had been diagnosed with bronchial asthma and was treated with a combination of inhaled corticosteroid and long‐acting beta2‐agonist. Blood examination showed ...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Conditions:   Atopic Dermatitis;   Pruritus;   Pruritus Chronic;   Dermatitis Interventions:   Drug: Naltrexone;   Other: Placebo Sponsor:   University of Minnesota Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Atopic dermatitis (AD) is known to negatively influence the mental health of patients. However, only a few studies have explored the influencing factors for psychiatric problems among adolescents with AD.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Conclusions: CCRT with cisplatin is effective for local control of ACC with manageable toxicity and may be an effective treatment option for locally advanced unresectable ACC. PMID: 32218101 [PubMed - as supplied by publisher]
Source: The Korean Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Korean J Intern Med Source Type: research
Conclusions: For HF-WBI, doses to nTIB over the prescription predicted acute toxicities independent of breast doses. These data support inclusion of TIB as a region of interest in treatment planning and protocol design. PMID: 32214909 [PubMed]
Source: Pain Physician - Category: Anesthesiology Authors: Tags: Rep Pract Oncol Radiother Source Type: research
Most cases of allergic contact dermatitis are localized to the area of skin that is exposed to the allergen; however, this is not always the case. When an allergen is ingested it may produce systemic contact dermatitis which is more difficult to diagnose. Unique features of the vulvar epithelium and environment make it susceptible to these reactions.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
Authors: Mendes JT, Balogh EA, Strowd LC, Feldman SR Abstract Introduction: Moderate-to-severe AD burdens a large proportion of AD patients and may represent an inadequacy of treatment options available for resistant disease.Areas covered: This review provides an overview of the therapies for moderate-to-severe AD in late-stage development and in the clinic, and focuses on baricitinib as an emerging therapeutic option. Baricitinib is an orally available selective JAK1/JAK2 inhibitor that is approved for use in the treatment of moderate-to-severe rheumatoid arthritis (RA). Baricitinib decreases AD lesions, disease s...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Publication date: Available online 27 March 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): M. Munera-Campos, J.M. Carrascosa
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
We examined the pattern of toll-like receptor 2 (TLR2), TLR4, TLR7, interleukin- (IL-) 10, interferon gamma (IFN-γ), and (program death ligand) PD-L1 gene expression in LST-positive reactions and paired normal-looking skin of nine infected Ibizan hound dogs. Healthy skin from ten seronegative dogs from a nonendemic area was analysed as a negative control. Immune gene expressions were examined by quantitative PCR (qPCR) analysis. LST-positive reactions presented significant upregulation of TLR2, TLR4, IL-10, IFN-γ, and PD-L1 and downregulation of TLR7 when compared with healthy skin of seronegative control dogs ...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
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