Chemical composition, antibacterial and antioxidant activities of some essential oils against multidrug resistant bacteria

Publication date: Available online 25 February 2020Source: European Journal of Integrative MedicineAuthor(s): Nait Irahal Imane, Hmimid Fouzia, Lahlou Fatima azzahra, Errami Ahmed, Guenaou Ismail, Diawara Idrissa, Kettani-Halabi Mohamed, Fahde Sirine, Ouafik L’Houcine, Bourhim Noureddine
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research

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Authors: Huang SX, Fan WY, Wang L, Liu H, Wang X, Zhao H, Jiang WB Abstract Maspin has been identified as a tumor suppressor gene in breast cancer, but the underlying regulatory mechanisms remain unclear. In the present study, maspin pcDNA was transfected into MCF-7 cells. microRNA (miR) microarray and reverse transcription-quantitative polymerase chain reaction was used for analysis; the results demonstrated that maspin may inhibit miR-10b, miR-21 and miR-451 expression in MCF-7 cells. In addition, maspin increased the expression of certain miR-21 target genes (phosphatase and tensin homolog, programmed cell death...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
This article reviews the spectrum of activity, the main pharmacokinetic and pharmacodynamic characteristics and the clinical efficacy and safety of ceftolozane-tazobactam in the treatment of HAP/VAP in adult patients.Expert opinion: The results of a randomized clinical trial have demonstrated an efficacy and safety profile of ceftolozane-tazobactam similar to that of its comparator for the treatment of patients with HAP/VAP. Several retrospective studies have shown good efficacy of the drug for the treatment of respiratory infections caused by MDR P. aeruginosa. The use of this drug may be incorporated as a new therapeutic...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
In this study, miRNA microarrays and bioinformatics methods were employed to determine the dysregulation of miRNA by IR in HCC cells, and quantitative RT-PCR (qRT-PCR) was applied to valid the miRNA array data. Of all the 2006 miRNAs screened, 32 miRNAs were found up or down regulated between the HepG2/IR cells and its parental cells. Further literature mining revealed that some of these miRNAs may function as oncogenes or tumor suppressors that contribute to tumor progression, recurrence, and metastasis which eventually lead to chemotherapeutic resistance. Interestingly, bioinformatics analysis by Gene Ontology (GO) enric...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
In conclusion, ensartinib may perpetrate clinically relevant pharmacokinetic DDIs and modulate ABCB1-, ABCG2-, and CYP3A4-mediated MDR. The in vitro findings presented here will provide a valuable foundation for future in vivo investigations.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
VOLUME 289 (2014) PAGES 21473–21489Since the publication of this article, further research has revealed mycoplasma contamination of the cell lines under investigation. In a separate article (Huff, L. M., et al. (2020) Mycoplasma infection mediates sensitivity of multidrug-resistant cell lines to tiopronin: a cautionary tale. J. Med. Chem. 63, 1434–1439), the authors demonstrate that the hypersensitivity of multidrug-resistant cell lines to tiopronin depends on mycoplasma infection. While the reported phenotype data are accurate in this Journal of Biological Chemistry article, the authors wish to add a Correctio...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Additions and Corrections Source Type: research
THURSDAY, March 26, 2020 -- Amongpatients with multidrug-resistant HIV-1 infection who have limited therapy options, reductions in HIV-1 RNA level were significantly greater in those who received fostemsavir compared with placebo during the first...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
elegh S, Katona K, Kristóf K Abstract Our objective was to compare the activity ceftazidime-avibactam (C/A) and ceftolozane-tazobactam (C/T) against multidrug (including carbapenem) resistant Pseudomonas aeruginosa clinical isolates collected from six diagnostic centers in Hungary and to reveal the genetic background of their carbapenem resistance.Two hundred and fifty consecutive, non-duplicate, carbapenem-resistant multidrug resistant (MDR) P. aeruginosa isolates were collected in 2017. Minimal inhibitory concentration values of ceftazidime, cefepime, piperacillin/tazobactam, C/A and C/T were determined b...
Source: Acta Microbiologica et Immunologica Hungarica - Category: Microbiology Authors: Tags: Acta Microbiol Immunol Hung Source Type: research
This study provides insights into how this deceptively complex pathway is regulated in the absence of a pathway specific master regulator, and how it might coordinate with the central metabolism of the cell.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
SSIs caused by multidrug-resistant gram-negative bacteria can pose treatment challenges. Learn about the currently available therapeutic options as well as those under development.Current Opinion in Infectious Diseases
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news
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