TERT Promoter Mutations Detectable 10 Years Prior to Bladder Cancer Diagnosis

This study provides the first evidence of the urinary TERT promoter mutations to be used as simple and cost-effective non-invasive biomarkers for the early detection of bladder cancer.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news

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Conclusion: Ho laser ERBT is safe and feasible for complete resection of NMIBCs with no risk of obturator-nerve reflex and a high rate of detrusor-positive specimens.
Source: Indian Journal of Urology - Category: Urology & Nephrology Authors: Source Type: research
ConclusionsWith good inter-observer concordance, the 2004 WHO classification system of noninvasive bladder tumours appears to accurately predict recurrence and progression risks. The combination of both grading systems to low-grade tumours allows further refinement of the natural history.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
The transcriptional data of circRNAs and mRNAs were deeply detected by high ‐throughput RNA sequencing and systematically analyzed using bioinformatics in patients with BC; and these eight dysregulated circRNAs were also verified by real‐time qRT‐PCR. Correlation analysis of clinicopathological features and survival analyses of circRNAs in BC were conducted. Functiona l experiments with circ_0077837 and circ_0004826 overexpression significantly weakened the progression of BC cells. AbstractGrowing evidence has indicated that circular RNAs (circRNAs) play crucial roles in multiple biological processes. However, altera...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
ConclusionIn the feasibility phase, the panel of urine biomarkers analyzed detected and predicted recurrence of NMIBC and provided reliable results in patients who had previously used intravesical BCG. Validation studies are required to confirm the panel clinical utility.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
AbstractPurposeTo assess the spectrum of computed tomography (CT) findings in patients with genitourinary cancers visiting the emergency room (ER) and evaluate the relationship between CT findings and overall survival (OS).MethodsRetrospective analysis of consecutive patients with genitourinary cancers undergoing CT during an ER visit at a tertiary cancer center during a 20-month period. CTs were considered positive if there were findings relevant to the presenting complaint(s). Demographic/clinical variables were recorded. OS was evaluated using Kaplan-Meier curves. Univariate and multivariate Cox proportional hazards reg...
Source: Emergency Radiology - Category: Emergency Medicine Source Type: research
Authors: Muşină AM, Huţanu I, Grigore M, Scripcariu IS, Filip B, Aniţei MG, Scripcariu DV, Gavrilescu MM, Radu I, Ioanid N, Pantazescu AN, Hogea M, Panuţa A, Buna-Arvinte M, Moraru GV, Scripcariu V Abstract Pelvic exenteration (PE) is an extensive surgical procedure for locally advanced primary neoplasia (LAPN) or recurrent neoplasia (RN) that consists in the en bloc removal of the pelvic organs (rectum, internal genital organs and bladder) associated with pelvic lymph nodes. PE is classified into anterior, posterior and total, supra or infralevatorian approaches. Our aim was to evaluate the surgical procedure...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
To evaluate the risk of occult nodal metastasis in patients with muscle invasive bladder cancer who exhibit a complete or partial clinical response to neoadjuvant chemotherapy (NAC) and assess a potential role for “bladder sparing” management given that the gold standard treatment, radical cystectomy (RC), is associated with high morbidity.
Source: Urology - Category: Urology & Nephrology Authors: Tags: Oncology Source Type: research
To evaluate the impact of alvimopan in patient undergoing radical cystectomy (RC) for bladder cancer. We hypothesize that alvimopan can decrease cost for RC by reducing length of stay (LOS).
Source: Urology - Category: Urology & Nephrology Authors: Tags: Health Services Research Source Type: research
AbstractInterest in and awareness of bladder cancer may translate to better health-seeking behaviors and earlier detection, given modifiable risk factors such as smoking. We assessed bladder cancer interest in the USA over the past 15  years as reflected by Internet search trends, and correlated these trends with epidemiologic patterns in bladder cancer. Google Trends was used to estimate US bladder cancer interest in the unit search volume index (SVI), which estimates the volume of online search activity for a specified period relative to the highest volume of searches within a specified location. Between January 200...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
AbstractPurpose of ReviewIt has been firmly established that hexaminolevulinate-assisted blue light cystoscopy (HAL-BLC) reduces cancer recurrence rates. This review explores the impact of HAL-BLC on other meaningful outcomes in patients with bladder cancer, including disease progression, and earlier detection of disease at the time of surveillance cystoscopy.Recent FindingsA randomized clinical trial confirmed earlier implementation of HAL-BLC at the time of surveillance cystoscopy increased identification of cancerous lesions, including those of high grade, when compared with white light cystoscopy. In addition, the evid...
Source: Current Urology Reports - Category: Urology & Nephrology Source Type: research
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